BACKGROUND Weaning from mechanical ventilation (MV) may be impeded by the occurrence of agitation. Loxapine has the ability to control agitation without affecting spontaneous ventilation. The aim of this study was to establish whether loxapine would reduce MV weaning duration in agitated patients. METHODS We performed a multicentre, double-blind, placebo-controlled, parallel group, randomised...

Resumo Objetivo Identificar a prevalência e os fatores de risco associados ao delirium em pacientes internados uma unidade terapia intensiva no nordeste do Brasil. Métodos Estudo transversal realizado entre julho 2017 abril 2018 com 316 hospitalizados por pelo menos 48h, ?18 anos, Richmond Agitation-Sedation Scale ? -3. A análise estatística incluiu univariada multivariada; um modelo log-binomi...

OBJECTIVE Deep sedation and delirium are common in the ICU. Mechanically ventilated patients with acute lung injury are at especially high risk for deep sedation, delirium, and associated long-term physical and neuropsychiatric impairments. We undertook an ICU-wide structured quality improvement project to decrease sedation and delirium. DESIGN Prospective quality improvement project in compa...

background: agitation is an early symptom of the acute opioid withdrawal syndrome in addicts that may start by inappropriate use of naltrexone. the current drug interventions are not efficient or need critical care as well. this study compares the clinical role of midazolam and diazepam for the management of agitation due to inappropriate use of naltrexone. materials and methods: in this double...

BACKGROUND The Richmond Agitation-Sedation Scale (RASS), which assesses level of sedation and agitation, is a simple observational instrument which was developed and validated for the intensive care setting. Although used and recommended in palliative care settings, further validation is required in this patient population. The aim of this study was to explore the validity and feasibility of a ...

Serial clinical examination represents the most fundamental and basic form of neurological monitoring, and is often the first and only form of such monitoring in patients. Even in patients subjected to physiological monitoring using a range of technologies, the clinical examination remains an essential tool to follow neurological progress. Key aspects of the clinical examination have now been s...

Sao Paulo Med J. 2008;126(4):215-9. Antonio Paulo Nassar Junior Ruy Camargo Pires Neto Walquiria Barcelos de Figueiredo Marcelo Park Validity, reliability and applicability of Portuguese versions of sedationagitation scales among critically ill patients Discipline of Medical Emergencies, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil CONTE...