Many lines of evidence suggest that the retinoblastoma protein interacting zinc finger gene RIZ is a strong candidate for the tumor suppressor locus on 1p36, a region commonly deleted in many human cancers with chromosomal instability. In addition, a role for RIZ in tumors of the microsatellite instability pathway is suggested by frequent frameshift mutations in hereditary non-polyposis colorec...

Mutations or changes in protooncogenes and tumor suppressor genes are casually linked to human cancer pathogenesis. The RIZ gene is isolated based on the capacity its gene products to bind to the retinoblastoma tumor suppressor protein. Consistent with a potential role in the Rb pathway, RIZ may play an important role in human cancer pathogenesis. RIZ maps to human chromosome band 1p36, a regio...

To identify a growth-promoting activity related to retinoblastoma-interacting-zinc-finger (RIZ) protein, differential protein expression of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of RIZ protein was analyzed by a robust bottom-up mass-spectrometry proteomic approach. Spots corresponding to qualitative and quantitative differences in protein expression have been se...

BACKGROUND Several studies have shown that microsatellite instability (MSI) is related to favourable survival in colorectal cancer patients but there are controversial results. Tumour suppressor gene RIZ is a susceptible mutational target of MSI. However, its clinicopathological significance has not been investigated. We investigated the prognostic significance of MSI in Swedish colorectal canc...

this research carried out in the rafsanjan pistachio orchard to investigate the effect of n form, manure, k and fe on yield, nut quality and leaf mineral nutrients concentrations of pistacia vera l. cv. fandoghi grafted on badami-riz zarand rootstock. the experiment was as factorial with four factors including; manure (without manure and 10 kg tree-1 sheep manure), n form (ammonium sulfate and ...

Histone methyltransferase (HMT) enzymes that methylate the lysine of histones are involved in chromatin-mediated gene expression. Previously, we reported that a novel polymorphism of SUV39H2, the HMT that is required for the methylation of H3-K9, was associated with an increased risk of lung cancer in Koreans. The retinoblastoma protein-interacting zinc finger gene RIZ (PRDM2) is also a member ...

Co-immunoprecipitation experiments in cell extract from cultured cells or target tissues indicated that estrogen receptor was complexed with the retinoblastoma binding protein RIZ in a ligand-dependent manner. Mapping of interaction sites indicated that in both proteins the same regions and motifs responsible for the interaction of transcriptional co-activator and nuclear receptors were involve...

Humic acid is a biochemical constituent of humus and increases root biomass and shoot growth by improving absorption of nutrients. In order to study the effects of humic acid on root and shoot growth and leaf nutrient contents of pistachio seedlings, an experiment was conducted of completely randomized design with five treatments in three replications. In the first step seeds of Pistacia vera c...