In eukaryotes, the complex comprised of Mcm2–7, Cdc45 and GINS (CMG) is essential for DNA replication. Several lines of evidence indicate that the Mcm2–7 complex is the motor of the replicative helicase (reviewed in ref. 1), which is activated by its association with Cdc45 and GINS. Recently, we described the isolation and characterization of the human (h) CMG complex. In HeLa cells, this compl...

Polymorphonuclear leukocyte (PMN) recruitment to sites of inflammation is initiated by selectin-mediated PMN tethering and rolling on activated endothelium under flow. Cell rolling is modulated by bulk cell deformation (mesoscale), microvillus deformability (microscale), and receptor-ligand binding kinetics (nanoscale). Selectin-ligand bonds exhibit a catch-slip bond behavior, and their dissoci...

As an important agronomic trait, rice (Oryza sativa L.) leaf rolling has attracted much attention from plant biologists and breeders. Moderate leaf rolling increases the photosynthesis of cultivars and hence raises grain yield. However, the relevant molecular mechanism remains unclear. Here, we show the isolation and functional characterization of SHALLOT-LIKE1 (SLL1), a key gene controlling ri...

High levels of regulated oncogen-alpha (GRO-a) expression have been observed in the liver. GRO-a stimulates proliferation of epithelial cells and induction of rolling and extravascular migration of neutrophils and mononuclear cells. Given the above observations, this chemokine was chosen to be analyzed in freshly isolated and cultured hepatocytes. In this study, hepatocytes (2×106 cell/ml) were...

there is a complicated relation between cold flat rolling parameters such as effective input parameters of cold rolling, output cold rolling force and exit thickness of strips. in many mathematical models, the effect of some cold rolling parameters has been ignored and the outputs have not a desirable accuracy. in the other hand, there is a special relation among input thickness of strips, the ...

..................................................................................................................................64 INTRODUCTION............................................................................................................................65 MATERIAL AND METHODS ...........................................................................................................

the forging model for cold rolling is one of rolling models that is used in rolling calculations. in this model,the final rolling pressure is an average value and it is not an accurate model.also by using this model,the firction hill curves are plotted due to the central point of the rolling bite length while frictional stresses intersect at the neutral point.in this study, a new model based on...