Introduction: A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson's disease (PD). Flavonoids like quercetin have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether quercetin administration at a high dose would attenuate behavioral abnormalities in e...

In this study electrical stimulation-induced rotational behavior was used as a behavioral index of mesostriatal dopamine (DA) activity to investigate gender and hormonal influences on the DA system. In female rats we found estrous cycle related variations in electrical stimulation-induced rotational behavior. A constant electrical stimulus produced significantly more turning on the day of estru...

The modulation of motor behavior by protein kinase C (PKC) signaling pathways in nigrostriatal neurons was examined by using a genetic intervention approach. Herpes simplex virus type 1 (HSV-1) vectors that encode a catalytic domain of rat PKCbetaII (PkcDelta) were developed. PkcDelta exhibited a constitutively active protein kinase activity with a substrate specificity similar to that of rat b...

torsion of many symmetric structures, which were designed based on the seismic codes, is due to their asymmetricity induced during inelastic behavior. although the structure was designed symmetrically assuming elastic based criteria, different factors such as material inconsistency in structure, construction details discrepancy and construction errors may result in asymmetric behavior in inelas...

A basic assumption of the 'rotational behavior model' is that amphetamine (AMPH) produces ipsiversive rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopamine (DA) system. However, we report here that if the normally 'dominant ' striatum is partially depleted of DA the majority of rats turn contraversive when given AMPH, i.e. in the opposite direction ...

introduction: animal models of parkinson’s disease (pd) with partial damage of nigrostriatal dopaminergic system are very suitable for development of treatment strategies. although drug-induced rotational behavior has been conventionally used for analysis of lesioned animals, but bcause of the development of sensitization, it is necessary to invent a pure behavioral test that can evaluate such ...