background: saccharin is an artificial non-caloric sweetener that used to sweeten products such as drinks, candies, medicines, and toothpaste, but our bodies cannot metabolize it. sodium saccharin is considered as an important factor in tumor promotion in male rats but not in humans. objective: the objective of this study was to investigate the effect of saccharin consumption on sperm parameter...

Food additives while attract consumers, improve quality, control weight and replace sugar, may affect seriously children and adults health. Here, we investigated the adverse effects of saccharin and methylsalicyltaes as sweetener and flavoring agent on lipid profile, blood glucose, renal, hepatic function and oxidative stress/antioxidants (lipid peroxidation, catalase and reduced glutathione in...

BACKGROUND Food additives attract consumers, improve foods quality, control weight, and replace sugar in foods, while it may affect seriously children and adults health. AIM To investigate the adverse effects of saccharin and methylsalicyltaes on lipid profile, blood glucose, renal, hepatic function, and oxidative stress/antioxidant (lipid peroxidation, Catalase and reduced glutathione (GSH) ...

Rats that are expecting a high value reward (e.g., 1.0 M sucrose) show an exaggerated underresponding when they are instead given a low value reward (e.g., 0.15% saccharin), an effect termed successive negative contrast (SNC). In the present experiment, insular cortex-lesioned (ICX) rats showed normal responsivity to sucrose and saccharin prior to the reward downshift. However, when switched fr...

Saccharin is carcinogenic for the urinary bladder in rats and mice, and most likely is carcinogenic in human beings. The neoplasms of the urinary bladder are malignant and invade and metastasize. Male rats are more susceptible to urinary bladder carcinogenesis than female rats. Rats exposed as fetuses develop neoplasms more readily than rats exposed as weanlings. The lesions in the urinary blad...

It has been shown that the occurrence of the preneoplastic lesion, papillary or nodular hyperplasia (PN hyperplasia) in rat urinary bladder induced by carcinogens is correlated with that of cancer. Therefore, the promoting effects of chemicals in two-stage bladder carcinogenesis were judged by measuring their ability to induce PN hyperplasia in rats. Male rats were given N-butyl-N-(4-hydroxybut...

Renwick & Williams (1972) showed that the gut flora of rats chronically fed with cyclamate acquire the ability to convert cyclamate into cyclohexylamine by splitting the N-S bond, although this did not occur in all rat colonies (Drasar et al., 1970). The splitting of the N-S bond in saccharin could occur similarly to form 2-sulphobenzamide. To investigate the possibility of similar variations i...

Operant testing is a widely used and highly effective method of studying cognition in rodents. Performance on such tasks is sensitive to reinforcer strength. It is therefore advantageous to select effective reinforcers to minimize training times and maximize experimental throughput. To quantitatively investigate the control of behavior by different reinforcers, performance of mice was tested wi...

Nickel is an essential engineering material and electrodeposited Ni has been widely used in many fields to improve surface finishing, corrosion resistance and wear properties. The kinetics of electrochemical deposition of nickel from chloride baths in the presence and absence of saccharin on the copper substrate was investigated by applying cyclic voltammetry and chronoamperometry measureme...

Incorporation of saccharin molecules has been studied during the galvanostatic deposition of 2.45 T CoFe alloys. The results indicate that the incorporation rate is strongly dependent on the concentration of saccharin in the plating solution. This dependence showed a pronounced maximum at Csac = 0.12 g L −1, which is a result with significant practical implications. A simple physical model was ...