background: salivary gland tumors are relatively uncommon and they consist of 3-10% of head and neck neoplasms. most of studies have shown geographic variation in the incidence and histopathologic types of salivary gland neoplasms. the aim of this study was to evaluate the salivary gland tumors in isfahan for 10 years duration. materials and methods: in this epidemiological study, 229 medical r...

Salivary gland involvement is one of the radioiodine therapy complications. Salivary gland scintigraphy in quantitative mode can accurately evaluate salivary gland function. Methods: Salivary gland scintigraphy was performed with Tc-99m Pertechnetate, at the time of iodine therapy as a basic study and then 3 weeks and 3 months afterwards. Ejection Fraction (EF) of parotid and submandibula...

Saliva is a useful biofluid for the early detection of disease, but how distal tumors communicate with the oral cavity and create disease-specific salivary biomarkers remains unclear. Using an in vitro breast cancer model, we demonstrated that breast cancer-derived exosome-like microvesicles are capable of interacting with salivary gland cells, altering the composition of their secreted exosome...

Salivary gland cancer although rare, is a disease with a high mortality rate, and a survival rate ranging from 20 to 40% at five or more years after diagnosis. A family of secreted glycoproteins known as SIBLING proteins has shown potential to be viable biomarkers in human salivary gland cancer. SIBLINGs are small, integrin-binding ligands with a soluble RGD motif that are expressed in minerali...

introduction: natural killer (nk) cells, of which cd56 is a specific marker, play an important role in host defense against tumors. cancer stem cells, of which aldehyde dehydrogenase isoform 1 (aldh1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. we aimed to evaluate the expression of aldh1 and cd56 in common salivary g...

hyalinizying clear cell carcinoma is a rare tumor which affects women more than men and is more common in minor salivary glands. the purpose of this paper was to describe a case of hyalinizing clear cell carcinoma of buccal vestibule in a 55-year-old woman. it is important to differentiate this neoplasm from other tumors with clear cell features because of their differences in treatment and cli...

OBJECTIVES To evaluate the risk of second primary cancers in patients with major salivary gland cancer using a large population database and to examine the effects of sex, salivary gland cancer histology, and radiation therapy on the risk of second primaries. STUDY DESIGN Population-based study using the Surveillance, Epidemiology, and End Result (SEER) cancer database. SUBJECT AND METHODS ...