Serotonin is an omnipotent molecule in the brain and rest of body plays a pivotal role gut-brain axis.Serotonin’s neurotransmission its function at molecular levels with different genetic variants has beenwidely covered across animal kingdom. Although digestion process ruminants pillared on anaerobicmicroflora present rumen, impact rumen microbial population serotonergic activity seldomexplored...

  Although cisplatin is one of the most effective cancer drugs which is widely used in the treatment of various neoplasms, its side effects, especially vomiting may limit its use. It has been demonstrated that cytotoxic drugs lead to a sudden release of serotonin (5-HT). The following study was performed to determine the possible interactions of cisplatin with 5-HT receptors. In this study, the...

Serotonin (5-HT), a mono-aminergic neurotransmitter is biochemically derived from tryptophan and is mainly found in gastrointestinal tract, platelets and central nervous system of animals. Serotonin (5-HT) in coordination with hypothalamus plays an important role in the CNS control of appetite, eating behavior, and energy balance and body weight. It has a special role in control of carbohydrate...

the regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using hplc methods. noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. the response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relatively i...

Abstract: Intracellular tryptophan (Trp) is catabolized to a large repertoire of metabolites via two major pathways: indoleamine and 2, 3-dioxygenases (IDO/TDO) Trp hydroxylase (TPH) pathways. The catabolites possess diverse biological activities carry out various physiological functions. Several such as kynurenine (Kyn) serotonin promote while melatonin 5-methoxytryptophan (5-MTP) suppress can...

2. Classification of Serotonin Receptors 1625 2.1. Gq/11-Coupled Receptor Types 1626 2.1.1. The 5-HT2A Receptor 1626 2.1.2. The 5-HT2B Receptor 1627 2.1.3. The 5-HT2C Receptor 1628 2.2. Gs-Coupled Receptor Types 1628 2.2.1. The 5-HT4 Receptor 1629 2.2.2. The 5-HT6 Receptor 1629 2.2.3. The 5-HT7 Receptor 1629 2.3. Gi/o-Coupled Receptor Types 1630 2.3.1. The 5-HT1A Receptor 1630 2.3.2. The 5-HT1B...

serotonin (5-ht), a mono-aminergic neurotransmitter is biochemically derived from tryptophan and is mainly found in gastrointestinal tract, platelets and central nervous system of animals. serotonin (5-ht) in coordination with hypothalamus plays an important role in the cns control of appetite, eating behavior, and energy balance and body weight. it has a special role in control of carbohydrate...

The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...

It has been hypothesized that a deficit in serotonin may be a crucial determinant in the pathophysiology of major depression. Serotonin-1A receptors are located on serotonin cell bodies in the midbrain dorsal raphe (DR) nucleus, and the activation of these receptors inhibits the firing of serotonin neurons and diminishes the release of this neurotransmitter in the prefrontal cortex. Repeated tr...

Background and Objective: It has been shown that the opioidergic system exerts widespread effects on cognitive functions. Interactions between opioid and serotonin receptors have been reported in some brain structures such as the dorsal hippocampus, thus a functional interaction between opioids and serotonin seems possible concerning memory control. The purpose of this study was to assess the e...