Background Frequent blood transfusion is often associated with iron overload. Proper use of iron chelators to treat iron overload requires an accurate measurement of iron levels. Magnetic resonance T2-star (T2* MRI) can measure iron level in the heart and liver. Our goal was to see whether an association exists between serum ferritin level and T2* MRI in patients with major beta thalassemia. ...

objective: breath holding spells, very often misinterpreted as epileptic seizures, are most common in children aged 6 months to 6 years of age. in this investigation, we sought to prospectively document the natural history of breath holding spells (bhs) among children with cyanotic, pallid and mixed type bhs referred for neurological consultation. materials & methods: this was a cross-sectional...

some recent studies have revealed the relationship among excess ferritin, coronary heart disease, and insulin resistance. to assess the association between serum ferritin concentration and impaired fasting glucose, this study was designed. a total of 187 people including 91 impaired fasting glucose (ifg) subjects and 96 normal glucose subjects who had been recognized in a large epidemiological ...

background transfusion-induced iron overload leads to many complications in patients with β-thalassemia major. this study aimed to compare the level of iron stored in the liver and heart measured by mri t2 * with ferritin levels in these patients. materials and methods this study was done on 52 patients with β-thalassemia major aged 7 to 29 years. serum ferritin level was checked and heart and ...

(1) Brief introduction to iron metabolism and the biochemistry of ferritin. (2) Early studies of circulating ferritin. (3) Methods for measuring serum ferritin concentrations -- immunoradiometric, radioimmuno- and enzyme-linked immuno assays based on liver or spleen ferritin -- an evaluation of these techniques. (4) Serum ferritin concentrations in normal subjects -- definition of normality -- ...

1. Serum samples were collected from ten patients hospitalized for acute infections and from a control group of seven normal subjects. Tissue ferritin was obtained by purification of ferritin from normal human liver and from the ferritin standard of a commercially available assay kit. 2. The serum and tissue samples were incubated with concanavalin A--Sepharose, which has the ability to bind no...

BACKGROUND In transfusion-dependent anaemias, while absolute serum ferritin levels broadly correlate with liver iron concentration (LIC), relationships between trends in these variables are unclear. These relationships are important because serum ferritin changes are often used to adjust or switch chelation regimens when liver magnetic resonance imaging (MRI) is unavailable. OBJECTIVES AND ME...

background: although it is assumed that calcium has beneficial effects on weight loss, the interaction of calcium and iron would be a major concern. we did this study to investigate the effects of calcium and low-fat milk on serum ferritin in overweight or obese premenopausal women.   methods: sixty-four healthy overweight or obese premenopausal women recruited in shahid beheshti university of ...