The recognition of replicating hepatitis B virus (HBV) may be important to both define the cause of and know how to manage chronic liver disease in multitransfused hemophilic patients. Replicating HBV can be detected at the molecular level by methods for HBV-specific DNA (HBV-DNA), which are much more sensitive than the immunologic methods for detecting hepatitis B surface antigen (HBsAg) and h...

OBJECTIVE This study aims to investigate the relationship between HBV DNA load and levels of serum HBsAg in patients with chronic hepatitis B (CHB). PATIENTS AND METHODS Between April 20013 and July 2015, serum samples were collected from 124 CHB patients. Levels of serum HBsAg was determined using chemiluminescent immunoassay and HBV DNA load was measured using quantitative fluorescent RT-PC...

Objective: To study the clinical value of hepatitis B virus pregenomic RNA (HBV-pgRNA) detection in treatment B. Methods: 60 patients with were included study. Serum HBV-pgRNA and HBV DNA levels different phases infection during detected, serum surface antigen (HbsAg) titer was detected by chemiluminescent immunoassay. extracted from liver biopsy tissue, covalently closed circular to predict th...

    Background: Hepatitis B Virus (HBV) causes acute and chronic liver disease worldwide. HBV has eight genotypes (A to H) which is the reflection of its genome with their characteristic geographical distribution. Each genotype could have different pathogenic and therapeutic characteristics. There have been few records on HBV genotyping in general population from our region. This study aimed to...

BACKGROUND Serum HBV RNA is detectable during nucleoside/nucleotide analogue therapy as a result of unaffected RNA replicative intermediates or interrupted reverse transcription. We studied the predictive value of serum HBV RNA for initial virological response during nucleoside analogue therapy. METHODS Serum HBV RNA was quantified before and at 12 and 24 weeks of lamivudine or entecavir ther...

background occult hepatitis b virus infection (obi) is defined as the presence of hepatitis b virus (hbv) dna in the liver and/or in the serum of patients with negative results of hepatitis b s antigen (hbsag) test with or without serological markers of previous viral exposure. the impact of obi in patients with chronic hepatitis c (chc) is still unclear. objectives the aim of this study was to...

BACKGROUND Detection of human hepatitis B virus (HBV) DNA in the urine of patients with chronic hepatitis B infection (CHB) has been reported previously, suggesting urine could provide a potential route of horizontal HBV transmission. However, it is not clear whether the HBV DNA detected in urine is indeed full-length, infectious viral DNA. The aim of this study is to assess the potential infec...

Studies are limited regarding the association between the quantity of hepatitis virus B (HBV) DNA loads in serum and peripheral blood mononuclear cells (PBMCs) in patients with drug resistance and few studies focus on the mutational pattern of the polymerase gene of HBV in PBMCs of patients with drug resistance. The aim of the present study was to investigate the association between the quantit...

OBJECTIVE To investigate the reactivation of the hepatitis B virus (HBV) following transarterial chemoembolization (TACE) in Chinese hepatocellular carcinoma (HCC) patients with low serum HBV DNA level, and to analyze the factors related to HBV reactivation in HCC patients with low serum HBV DNA level. METHODS From November 2011 to January 2014, 109 patients newly diagnosed with HCC with an H...