Two patients with penile skin loss who were operated in 1991 are reviewed retrospectively. In both of them skin grafting was mandatory (due to large skin defects on the penile shaft). Causative factors were localized infection in one case and verrucae accuminata in another. In both cases a random flap from the skin of the inner surface of the thigh was applied. The pedicle flap was later t...

the distal third of the tibia, ankle and heel area is difficult to reconstruct. for small to medium size defects, local flaps are often an easier alternative than free flap. in lower limb surgery, the sural flap is based on this principle and this flap is becoming increasingly popular. the distally based superficial sural artery flap, first described as a distally based neuro skin flap by masqu...

Despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. Therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. In present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...

Background: Skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. In a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on tissue survival in a rat model of skin flap grafting. In the current study, we investigated the involvement of nitric oxide and inducible nitric o...

two patients with penile skin loss who were operated in 1991 are reviewed retrospectively. in both of them skin grafting was mandatory (due to large skin defects on the penile shaft). causative factors were localized infection in one case and verrucae accuminata in another. in both cases a random flap from the skin of the inner surface of the thigh was applied. the pedicle flap was later transe...

Distal skin ischemic necrosis is a common complication in skin flap surgery. The pathogenesis of skin flap ischemic necrosis is unclear, and there is no clinical treatment available. Here, we used the 4 x 10 cm rat dorsal skin flap model to test our hypothesis that subcutaneous injection of vascular endothelial growth factor 165 (VEGF165) in skin flaps at the time of surgery is effective in aug...

background one of the main challenges in skin flap surgery is tissue ischemia and following necrosis. the present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. methods thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal random-pattern skin ...