Immunochemical relatedness of preparations of purified somatotropins (growth hormones) of somatotropins in pituitary extracts from various vertebrate species was investigated by applying an antiserum to a purified somatotropin from a submammalian species, the snapping turtle. With the exception of monkey somatotropin, all mammalian, reptilian, and avian preparations tested showed reactions of i...

Sixteen barrows and gilts (sex effects were balanced within treatment, but not included in the model for analysis) were used in a 2 (porcine somatotropin; 2 mg.animal-1.d-1 vs control) X 2 (10% dietary fat vs control) X 4 (time postmortem; 0, 3, 6, and 24 h) factorial treatment array to evaluate the effects of porcine somatotropin (pST) administration and level of dietary fat intake on the func...

The objectives of this study were to investigate the effects of exogenous somatotropin on growth performance and carcass traits and on concentrations of somatotropin (ST), IGF-I, insulin, glucagon, free fatty acids (FFA), and glucose in plasma of finishing Simmental beef heifers. Three treatment groups, which included 12 heifers each, received a subcutaneous injection of a slowly released recom...

Following hypophysectomy of the rat, partial involution occurs in the zymogenic cells of the stomach (Baker and Abrams, '54), parotid gland (Baker and Abrams, '55), pancreas (Baker and Pliske, '57) , submandibular gland (Lacassagne and Chamorro, '40 ; Grad and Leblond, '49) , and in the intestinal cells of Paneth (Baker, Kent and Pliske, in press). Insofar as they have been studied, enzyme synt...

The intracellular signal transduction mechanisms mediating maturational gonadotropin and somatotropin secretion in goldfish are reviewed. Several major signaling mechanisms, including changes in intracellular [Ca2+], arachidonic acid cascades, protein kinase C, cyclic AMP/protein kinase A, calmodulin, nitric oxide, and Na+/H+ antiport, are functional in both cell types. However, their relative ...

Osteoporotic fractures are the result of low density and especially inferior bone quality (microarchitecture) caused by both internal (genes, hormones) and external (life style) influences. Bone mechanosensors are extremely important for the overall integrity of the skeleton, because in response to mechanical load they activate its modeling, resulting in an increase in bone density and strength...

The effects of the p-adrenergic agonists (BAA) and somatotropin on livestock species are well documented and have been the topic of discussion at previous conferences (see RMC proceedings 1984, 1985, 1987). These agents markedly alter carcass composition, i.e., they decrease fat deposition and increase muscle mass. The BAA appear to have their greatest effect on muscle hypertrophy, while somato...

The prostaglandin E content of dispersed rat anterior pituitary glands was found to increase in the presence of phospholipase A or arachidonic acid. The increases were abolished by the addition of indomethacin. Similarly, the rate of somatotropin (growth hormone) synthesis was increased by these two agents, and the increases were again abolished by indomethacin. Phospholipase A also stimulated ...

Recombinant bovine somatotropin (rBST) changes metabolism to spare glucose for milk synthesis in cows. Ceramides inhibit insulin responsiveness adipocytes and are associated with resistance production The mechanisms by which rBST supports lactation may involve ceramide. Eight multiparous lactating Holstein cows were enrolled a 2 × replicated Latin square design 14-d periods. Cows received singl...