The polypeptide hormone stanniocalcin-1 (STC-1) is widely expressed in mammals and signals both locally and systemically. In many tissues STC-1 ligand is sequestered by target cell organelles (mitochondria, nuclei, and cholesterol lipid droplets) to exert diverse biological effects. Most notably, STC-1 serves as an uncoupler of oxidative phosphorylation in liver, muscle, and kidney mitochondria...

Stanniocalcin-1 (STC-1) was first identified to involve in Ca(2+) homeostasis in teleosts, and was thought to act as a hypocalcemic hormone in vertebrate. Recent studies suggested that STC-1 exhibits broad effects on ion balance, not confines to Ca(2+), but the mechanism of this regulation process remains largely unknown. Here, we used zebrafish embryos as an alternative in vivo model to invest...

Various space time code (STC) designs have been proposed to obtain full diversity at full rate in multiple-input multiple-output (MIMO) channels for uncoded systems. However, commercial wireless systems typically employ powerful channel codes such as turbo codes and low density parity check (LDPC) codes together with an STC. For these applications, an STC optimized for uncoded systems may not p...

Results clustering in Web Searching is useful for providing users with overviews of the results and thus allowing them to restrict their focus to the desired parts. However, the task of deriving singleword or multiple-word names for the clusters (usually referred as cluster labeling) is difficult, because they have to be syntactically correct and predictive. Moreover efficiency is an important ...

Fish stanniocalcin (STC) inhibits uptake of calcium and stimulates phosphate reabsorption. To determine the role of the highly homologous mammalian protein, STC-1, we created and characterized transgenic mice that express STC-1 under control of a muscle-specific promoter. STC-1 transgenic mice were smaller than wild-type littermates and had normal growth plate cartilage morphology but increased...

Kidney collecting duct principal cells are the main source of stanniocalcin-1 (STC-1) production and secretion. From there, the hormone targets thick ascending limb and distal convoluted tubule cells, as well as collecting duct cells. More specifically, STC-1 targets their mitochondria to exert putative antiapoptotic effects. Two distal tubule cell lines serve as models of STC-1 production and/...

In mammals, the ovaries have the highest levels of stanniocalcin (STC) gene expression, most or all of which is confined to androgen-producing thecal-interstitial cells (TICs). Ovarian TICs also synthesize a different STC that consists of three high molecular weight species collectively known as big STC. Upon release in response to LH stimulation, TIC-derived big STC is sequestered locally by t...

We present the multi-layer extension of the Sparse Ternary Codes (STC) for fast similarity search where we focus on the reconstruction of the database vectors from the ternary codes. To consider the trade-offs between the compactness of the STC and the quality of the reconstructed vectors, we study the rate-distortion behavior of these codes under different setups. We show that a single-layer c...

The corpuscles of Stannius are responsible for the synthesis and secretion of stanniocalcin (STC), a glycoprotein hormone that regulates calcium and phosphate homeostasis in fishes through its actions on the gills and kidneys. The corpuscles of Stannius and STC are considered to be an endocrine system that is unique to fishes. In this report, we provide evidence for the existence of STC-like pr...