objective: objective: dermal papilla and hair epithelial stem cells regulate hair formation and growth cycle. damage to or losing of these cells can cause hair loss. although several studies have claimed to reconstitute hairs using rodent cells in animal model, a stable human hair follicle reconstitution protocol needs more studies. here in this study we evaluated hair induction through injecti...

Stem cells of the apical papilla (SCAP) represent great promise regarding treatment of neural tissue damage, such as spinal cord injury (SCI). They derive from the neural crest, express numerous neurogenic markers, and mediate neurite outgrowth and axonal targeting. The goal of the present work was to investigate for the first time their potential to promote motor recovery after SCI in a rat he...

Purpose: To investigate the use of tricalcium silicate cement Biodentine as an alternative to MTA in regenerative endodontic procedures by assessing morphology and adhesion stem cells from apical papilla direct contact with these materials Materials/Methods: Glass ionomer cement, disks identical size were created. Stem incubated on disks, their assessed a scanning electron microscope. Results: ...

Purpose: To investigate the effect of triiodothyronine (T3) in odontoblast differentiation apical papilla stem cells, and mechanism action involved.
 Methods: Apical unclosed permanent molars extracted from patients due to orthodontics impaction were selected. The teeth cultured isolation stage SCAP cells. cells exposed different concentrations T3. effects ERK p38 MAPK signaling pathways o...

The tooth root transmits and balances occlusal forces through the periodontium to the alveolar bone. The periodontium, including the gingiva, the periodontal ligament, the cementum and the partial alveolar bone, derives from the dental follicle (DF), except for the gingiva. In the early developmental stages, the DF surrounds the tooth germ as a sphere and functions to promote tooth eruption. Ho...

Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment. A call for a paradigm shift and new protocol for the clinical management of these cases has been brought to attention. Concomitantly, a new population of mesenchymal stem cells residing in the apical papilla of permanen...

The interaction between stem cells and growth factors plays a major role in the regeneration of pulp-dentin complex. Studies have reported potential Bone Morphogenic Proteins (BMPs) differentiation cells. purpose present systematic review was to analyze Protein-2 (BMP-2) osteogenic/odontogenic Stem from apical papilla (SCAP). search conducted across PubMed, Science Direct, Cochrane Library, Goo...