introduction: post-endodontic pain is one of the main problems for both patients and dentists. the purpose of this study was to compare the effectiveness of premedication with indomethacin and ibuprofen for management of postoperative endodontic pain. methods and materials: in this clinical trial, mandibular molars with irreversible pulpitis were endodontically treated in 66 patients. the medic...

introduction : post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. the purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of zingiber officinale , zintoma , and ibuprofen on post endodontic pain of molars with irreversible pulpitis. materials and methods: the post endo...

background: although helicobacter pylori and non-steroidal anti-inflammatory drugs (nsaids) are the main causes of peptic ulcers disease (pud), recently the prevalence of idiopathic peptic ulcer (ipu) is increasing in most parts of the world. the aim of this study was to assess the prevalence of ipu in kerman, the center of largest province in south-east iran. methods : we included 215 patients...

Recent studies using small bowel endoscopy revealed that non-steroidal anti-inflammatory drugs including low-dose aspirin, can often induce small bowel injury. Non-steroidal anti-inflammatory drugs-induced small bowel mucosal injury involves various factors such as enterobacteria, cytokines, and bile. Experimental studies demonstrate that both mitochondrial disorders and inhibition of cyclooxyg...

About 5% of all National Health Service prescriptions in Britain and a quarter of reports of suspected adverse reactions are accounted for by non-steroidal anti-inflammatory drugs. Their prescription was investigated in two computerised group practices serving 11850 patients. Altogether 198 patients receiving repeat prescriptions of non-steroidal anti-inflammatory drugs were identified and rele...

OBJECTIVE To estimate the risk of acute hepatotoxicity associated with nimesulide compared with other non-steroidal anti-inflammatory drugs. DESIGN Retrospective cohort and nested case-control study. SETTING Umbria region, Italy. PARTICIPANTS 400 000 current, recent, and past users (almost 2 million prescriptions) of non-steroidal anti-inflammatory drugs between 1 January 1997 and 31 Dece...

The incidence of non-steroidal anti-inflammatory drug-related ulcer complications remains high despite the availability of potent anti-ulcer drugs and selective cyclo-oxygenase-2 inhibitors. Non-steroidal anti-inflammatory drug-related ulcer complications can be minimized by prospective assessment of patients' baseline risk, rational choice and use of non-steroidal anti-inflammatory drugs, and ...

The effects of steroidal and non-steroidal anti-inflammatory drugs on the established lesion of type II collagen induced arthritis in rats were evaluated by measuring the hind paw oedema and anti-type II collagen antibody titre. Dexamethasone, a steroidal anti-inflammatory drug, reduced the anti-type II collagen antibody titre and markedly suppressed the established lesion of type II collagen i...

background: peritendinous adhesions after repairing an injury to the digital flexor tendons are a major problem in hand surgery. non-steroidal anti-inflammatory drug therapy may affect tendon healing and the development of peritendinous adhesions. the aim of this study was to evaluate ibuprofen effect in patients function after flexor tendon surgical repair.   method: thirty-five patients, who ...