the effect of endogenous serotonin on long-term potentiation (ltp) in region cai was studied by blocking 5-ht2 receptors with ketanserin in rat hippocampal slices. such a block significantly en-hanced long-term potentiation of the cai population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. this implies that serotonin acts on 5-ht2 receptors in cai...

Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulation. The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in excitatory synaptic tran...

long-term potentiation (ltp) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. the first clue of the potential role of glutamate receptors in ltp was in 1991 with the observation that the mglur agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (acpd), increased ltp. studies have shown that acpd induc...

objective(s) the objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (csd) in rat brain. cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. csd is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. materials and methods the ...

objective(s):neurodegenerative alzheimer’s disease (ad) is associated with profound deficits in synaptic transmission and synaptic plasticity. long-term potentiation (ltp), an experimental form of synaptic plasticity, is intensively examined in hippocampus. in this study we evaluated the effect of aqueous extract of lavender (lavandula angustifolia) on induction of ltp in the ca1 area of hippoc...

“Supplementary Figure 1. Effect of activity blockade on synaptic area, levels of Homer and Bassoon, Homer-Bassoon colocalization values in three independent experiments, and the relationship between the colocalization values and synaptic properties. (A) TTX treatment does not affect the size of synaptic clusters. P > 0.05, Mann-Whitney test. (B) TTX treatment increases synaptic levels of Homer....

background and objective: sciatic nerve transection is characterized by a rapid wave of motoneuron death associated with progressive synaptic lesions. the purpose of this study was to evaluate the long term synaptic changes. materials and methods: this basic study was carried out on paraffin- or resin-embedded tissue blocks for evaluation of synaptophysin and choline acetyl transaferase (chat) ...

Background and Objective: Sciatic nerve transection is characterized by a rapid wave of motoneuron death associated with progressive synaptic lesions. The purpose of this study was to evaluate the long term synaptic changes. Materials and Methods: This basic study was carried out on paraffin- or resin-em...