BACKGROUND Membrane proteins define biological functions of membranes in cells. Extracellular peptides of transmembrane proteins receive signals from pathogens or environments, and are the major targets of drug developments. Despite of their essential roles, membrane proteins remain elusive in topological studies due to technique difficulties in their expressions and purifications. METHODS Fi...

objective: in this project, our aim was to construct a novel expressing vector harboring a new sequence from overlapping region of ns3 gene of hcv from infected iranian patient. materials and methods: the partial ns3 (pns3) gene was amplified by nested-rt-pcr method using sera of hcv infected patients harboring genotype 1a. after purification and cloning the pns3 into ta-cloning vector, the be...

The KK/Ta strain serves as a suitable polygenic mouse model for the common form of type 2 diabetes associated with obesity in humans. Recently, we reported the susceptibility loci contributing to type 2 diabetes and related phenotypes in KK/Ta mice. In this study, we focused on expression in the kidneys and liver of KK/Ta and BALB/c mice using differential display (DD) PCR. Zn-alpha(2) glycopro...

Many formulations of visual reconstruction problems (e.g., optic pow, shape from shading, biomedical motion estimation from CT da ta ) involve the recovery of a vector field. Often the solution is characterized via a generalized spline or regularization formulation using a smoothness constraint. This paper introduces a decomposition of the smoothness constraint into two parts: one related to th...

The representations of dimension vector α of the quiver Q can be parametrised by a vector space R(Q,α) on which an algebraic group Gl(α) acts so that the set of orbits is bijective with the set of isomorphism classes of representations of the quiver. We describe the semi–invariant polynomial functions on this vector space in terms of the category of representations. More precisely, we associate...

In this section, we describe in detail the analytical solutions to compute the layer thicknesses and translation along the axis when refractive indices are unknown. As shown in the paper, the axis can be computed independently of the layer thicknesses and refractive indices. We assume that axis A, rotation R and translation orthogonal to the axis, tA, has been computed as described in Section 3...

This work considers the Real Leja Points Method (ReLPM), [J. Comput. Appl. Math., 172 (2004), pp. 79–99], for the exponential integration of large-scale sparse systems of ODEs, generated by Finite Element or Finite Difference discretizations of 3-D advectiondiffusion models. We present an efficient parallel implementation of ReLPM for polynomial interpolation of the matrix exponential propagato...

Many geographical databases have been developed for different programs and applica tions/ but da ta acquisition and da ta sharing are still a big problem because no interoperability exists among these different da tabases. This study presents a GML (Geography Markup Language) approach to build a geographical da tabase in order to enable interoperability. As an open/ non-proprietary industry sta...

This paper focuses on oncolytic Newcastle disease virus (NDV). This paper summarizes (i) the peculiarities of this virus as an anti-cancer and immune stimulatory agent and (ii) the approaches to further harness this virus as a vector to combat cancer. Special emphasis is given on combining virus therapy with cell therapy and on improving tumor targeting. The review will include some of the auth...