The action of a novel cardiotonic agent N-hydroxy-5,6-dimethoxy-benzo[b]thiophene-2-carboximide hydrochloride (Org 30029) on intracellular aequorin light transients and isometric contractions was investigated in isolated canine ventricular trabeculae. The positive inotropic effect of Org 30029 (30 ,uM-3 mM) was consistently associated with prolongation of the duration of contraction and an incr...

The neuromuscular and cardiovascular activities of pancuronium were compared with those of its 16(3 monoquaternary congener, Org NC 45, in the anaesthetized rat, cat and rhesus monkey. In the rat Org NC 45 was 3.4 times less potent as a neuromuscular blocking agent than was pancuronium. In the cat, both drugs were found to be approximately equally eliminated by the liver, whereas renal eliminat...

The neuromuscular blocking effects of Org 6368 and Org NC 45 were studied in rats with experimental cholestasis and in controls. The effect of Org NC 45 during infusion of taurocholate was investigated. In cholestatic rats we observed a three-fold increase of the duration of action of Org 6368 and Org NC 45. The same was observed for Org NC 45 with taurocholate. In the rat phrenic nerve-hemidia...

OBJECTIVE(S) The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors. MATERIALS AND METHODS Cannula was inserted into left ventricle of male rats. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6 µg / ra...

Soil environmental variability and fungal community structures were analyzed to evaluate differences in soils managed under organic (ORG) and conventional (CNV) systems of farming in Fukushima and Yamagata prefectures in Japan. The soils were collected from 8 ORG and 13 CNV farms in 2005, and 6 ORG and 13 CNV farms in 2006. Principal component analysis (PCA) of 26 environmental variables demons...

BACKGROUND At present, reversal of neuromuscular block induced by steroidal neuromuscular blocking agents (NMBAs) is achieved by administration of cholinesterase inhibitors. Chemical encapsulation of steroidal NMBAs, such as rocuronium, by a cyclodextrin is a new concept in neuromuscular block reversal. The present study evaluates the capacity of nine synthetic cyclodextrin derivatives (Org 252...

Members of the T-Box gene family of transcription factors are important players in regulatory circuits that generate myogenic and cardiogenic lineage diversities in vertebrates. We show that during somatic myogenesis in Drosophila, the single ortholog of vertebrate Tbx1, optomotor-blind-related-gene-1 (org-1), is expressed in a small subset of muscle progenitors, founder cells and adult muscle ...

objective(s) the objective of this study was to determine the effect of aqueous extract of origanum vulgare l. ssp. viridis (org) on discrimination learning and long term potentiation (ltp) in ca1 region of the rat hippocampus. materials and methods a group of adult male wistar rats weighing 275±25 g received aqueous extract of org (150, 300, 450 mg/kg/day) by intraperitoneal injection for one ...