today, “civil order” may be regarded as one of the most important “functional requirements” (fr) of any city, as a real, complex, large-scale system. in this regard, learning about dynamic behavior of the civil order phenomenon and analysis of all information obtained from “operational environment” associated with the system of interest may be considered an essential step in the process of “cri...

  Objective(s): The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors.   Materials and Methods: Cannula was inserted into left ventricle of male rats. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6 μg ...

Objective(s) The objective of this study was to determine the effect of aqueous extract of Origanum vulgare L. ssp. Viridis (ORG) on discrimination learning and long term potentiation (LTP) in CA1 region of the rat hippocampus. Materials and Methods A group of adult male Wistar rats weighing 275±25 g received aqueous extract of ORG (150, 300, 450 mg/kg/day) by intraperitoneal injection for one ...

the objective of the present investigation was to assess the possible involvement ofgabaergic mechanism in analgesic effect of aqueous extract of origanum vulgare (org)in a rat model of acute pain test. sixty-three anaesthetized male wistar rats (200-250 g) werecannulated into the left ventricle. five to seven days after the recovery from surgery, org extractwas intraventricularly injected at d...

objective(s): the aim of study was to investigate the antinociceptive effect of intracerebroventricular (icv) microinjection of origanum vulgare (org) extract and possible involvement of opioid receptors.   materials and methods: cannula was inserted into left ventricle of male rats. five days after surgery tail flick latency (tfl) was measured after icv microinjection of, org (1, 3 and 6 μg / ...

Vecuronium is hydrolyzed in the body to 3-deacetyl (ORG 7268), 17-deacetyl (ORG NC58), and 3, 17-bis-deacetyl (ORG 7402) derivatives. Interactions of vecuronium and these metabolites were studied in phrenic nerve-hemidiaphragm preparations of rats. As already reported, ORG 7268 had a potent neuromuscular blocking action, and ORG NC58 and ORG 7402 had a weak neuromuscular blocking action. As exp...

The action of a novel cardiotonic agent N-hydroxy-5,6-dimethoxy-benzo[b]thiophene-2-carboximide hydrochloride (Org 30029) on intracellular aequorin light transients and isometric contractions was investigated in isolated canine ventricular trabeculae. The positive inotropic effect of Org 30029 (30 microM-3 mM) was consistently associated with prolongation of the duration of contraction and an i...

The action of a novel cardiotonic agent N-hydroxy-5,6-dimethoxy-benzo[b]thiophene-2-carboximide hydrochloride (Org 30029) on intracellular aequorin light transients and isometric contractions was investigated in isolated canine ventricular trabeculae. The positive inotropic effect of Org 30029 (30 ,uM-3 mM) was consistently associated with prolongation of the duration of contraction and an incr...