BACKGROUND Cytochrome P450s (CYPs) influence the biological effects of carcinogens, drugs and hormones including testosterones. Among them, Cytochrome P450 2B6 (CYP2B6) plays a critical role in the deactivation of testosterone. In the present study, we examined CYP2B6 expression in human prostate tissues and prostate cancer. METHODS Immunohistochemical analysis was performed in 98 benign and ...

Human cytosolic sulfotransferases (SULT) 2A1 is the main enzyme involved in the sulfate conjugation of dehydroepiandrosterone, a weak androgen, and the main androgen precursor, whereas estrogens are mainly conjugated by SULT1A1. Here we have identified a copy number variation (CNV) polymorphism in the SULT2A1 gene in a Swedish population including healthy men (N = 30). Moreover, the CNV of SULT...

The effects of the main male and female sex hormones, testosterones and estradiol, in pokeweed mitogen (PWM)-stimulated cultures of human blood lymphocytes were studied. We found that the addition of physiological concentrations of estradiol (780-2,600 pmol/liter) to PWM cultures significantly increased the accumulation of immunoglobulin M-containing and -secreting cells detected by immunofluor...

Background: Polycystic ovary syndrome (PCOS) has taken the prime position as an endocrine disease in women of reproductive age and is estimated to affect 2.2–22.5% worldwide Indian it ranges from 9% 12%. The primary defects that cause PCOS still remains unknown. A lot genetic factors not excluding polymorphisms mutations multiple genes have been linked with PCOS, exact mechanisms which might be...

BACKGROUND Alpinia galanga (A. galanga) belongs to the Zingiberaceae family has anti-oxidant effects in animals and humans body and often is used as medicament or part of medicaments in Asian folk medicine for various applications. OBJECTIVE The objective of this study was to investigate the molecular and biochemical influence of alcoholic extract from the rhizomes of A. galangal on the sperm...

Background Ginseng is often referred to as the King of all herbs, and is found to be a promising agent to improve general well-being. Ginseng has also been reputed as an aphrodisiac, a disused to treat sexual dysfunction as well as to enhance sexual behavior. MaterialsAndMethods In this trial, thirty three adult male rats were divided into three groups. Experimental groups received gensing oral...

Background: Phytoestrogens are some plant compounds with estrogenic biological effects which are found in many nutritional sources as soybean, flaxseed, and sesame. Vitex agnus-castus, also called Vitex, owns  phytoestrogen properties. Studies have shown that phytoestrogens have different impacts on the gestation process and reproduction indices. Objective: The present study was aimed to inves...

Background Spermatogenesis is a process in which the gametes are produced. Dysfunction in any of part of the process could result in infertility. Tribulus terrestris is a flowering plant which traditionally is used to sexual instinct. Reports indicate that this plant could elevate blood levels testosterone and enhance libido. MaterialsAndMethods In this experimental study, twenty six mature inb...

The chronic exposure to ELF-EMF (extremely-low frequency electromagnetic field) has been shown as an effective factor at biological systems. In order to determine the possible effects of whole-body exposure to EMF on plasma levels of testosterones and corticosterone, weight gain and testicular gene expression of Gstt1 of male rats, the present study was performed by the following procedure: thi...

background: phytoestrogens are some plant compounds with estrogenic biological effects which are found in many nutritional sources as soybean, flaxseed and sesame. vitex agnus-castus, also called vitex, owns phytoestrogenic properties. studies have showed that phytoestrogens have different impacts on the gestation process and reproduction indices. the present study is aimed at investigating the...