A number of metabolic factors and the activity of a number of enzymes were determined in meal-fed (animals fed a single daily 2 hr meal) and nibbling (ad libitum-fed) rats. The dependency of the observed adaptive changes on the ingestion of carbohydrate was studied by feeding diets high in carbohydrate or fat. Glucose-6-phosphate dehydrogenase and NADP-malic dehydrogenase were more active in ad...

The effect of zinc deficiency on the function of the intestine to absorb water and electrolytes was studied in animal models, stimulated by Vibrio cholerae enterotoxin. Sprague-Dawley rats, used in the study, were divided into four groups: Zinc-deficient, ad libitum zinc-fed control, zinc weight-matched control, and zinc-deficient acutely-repleted. 14C-labelled polyethylene glycol solution was ...

The effects of body size and feed intake on N digestibility, pancreas and liver weight, and digestive enzyme activities in male broiler chicks were compared with those induced by dietary tannins. Four groups (SSM, ad lib., pair-fed and young) of sixteen birds each (2 weeks old) were used as experimental animals. They were fed on experimental diets for 4 weeks, except the young group which were ...

A complete diet (Total Mixed ration) with sorghum stover (40%) as sole roughage source was prepared and offered to animals under two forms: as mash or as expanded-extruded pellets (EEP). These two complete diets were compared with a conventional diet (ad libitum chopped sorghum stover fed separately with concentrate mixture to meet 80% of protein requirements). These three diets were randomly a...

The intrinsic contractile properties of isolated left ventricular trabecular periods of 24, 40, and 53 days were compared with those from 35 weight-matched food-deprived animals and 25 ad libitum fed controls. Contraction mechanics were measured for each muscle when stretched to the peak of its length tension curve at 28 degrees C in oxygenated Krebs-Henseleit solution. Although both thiamine-d...

The effect of vitamin A deficiency on the immune response to epizootic diarrhoea of infant mice (EDIM) rotavirus was studied in mice. The virus was given by oral dosing or by intraperitoneal injection. For oral challenge, weanling mice were fed on either a control or vitamin A-deficient diet ad lib. or pair-fed the control diet to the intake of the vitamin A-deficient group. A fourth group was ...

The aims of this study were to determine in the marsupial Sminthopsis crassicaudata, the effects of leptin on food intake, body weight, tail width (a reflection of fat stores), and leptin mRNA, after caloric restriction followed by refeeding ad libitum with either a standard or high-fat preferred diet. S. crassicaudata (n = 32), were fed standard laboratory diet (LabD; 1.01 kcal/g, 20% fat) ad ...

Melanin-concentrating hormone (MCH) is a cyclic orexigenic peptide expressed in the lateral hypothalamus. Recently, we demonstrated that chronic intracerebroventricular infusion of MCH induced obesity accompanied by sustained hyperphagia in mice. Here, we analyzed the mechanism of MCH-induced obesity by comparing animals fed ad libitum with pair-fed and control animals. Chronic infusion of MCH ...

BACKGROUND AND PURPOSE Hypercholesterolemia is associated with endothelial dysfunction. Inducible nitric oxide synthase (iNOS) is upregulated in atherosclerotic vessels. However, its role in the regulation of vascular function is not completely understood. We examined the effect of adenovirus-mediated gene transfer of iNOS to the hypercholesterolemic rabbit carotid artery in vivo. METHODS Rab...

Insulin resistance is a feature of most patients with type 2 diabetes mellitus. Epidemiological evidence suggests a correlation between inflammation and insulin resistant states such as obesity, but the underlying mechanisms are largely unknown. Interleukin-1 receptor-associated kinases (IRAK) play a central role in inflammatory responses by regulating the expression of various inflammatory gen...