The mechanical properties of lung tissue are important determinants of lung physiological functions. The connective tissue is composed mainly of cells and extracellular matrix, where collagen and elastic fibers are the main determinants of lung tissue mechanical properties. These fibers have essentially different elastic properties, form a continuous network along the lungs, and are responsible...

Needle insertion is a minimally invasive technique in diagnosing and treating tumors. However, to perform a surgery accurately, the tissue should have minimum amount of displacement during needle insertion so that it reaches the target tissue. Therefore, the tissue membrane has to move less to decrease rupturing under the membrane. In this study, the effect of different design parameters on dis...

Di erent mechanical properties of biological tissues depend on mineral content. Thus, roughly, it can be distinguished two classes of biological tissues. Bones and tooth content mineral, they conform the group known as hard tissues. Whereas, skin, muscle, blood vessel and lungs conform the second group called of soft tissues. They do not content mineral, so they are much deformable than hard ti...

The mechanical properties of lung parenchymal tissue are both elastic and dissipative, as well as being highly nonlinear. These properties cannot be fully understood, however, in terms of the individual constituents of the tissue. Rather, the mechanical behavior of lung tissue emerges as a macroscopic phenomenon from the interactions of its microscopic components in a way that is neither intuit...

Collagen fibers form the basic structural components of the extracellular matrix (ECM) of vertebrates that serve to: store elastic energy during muscular deformation, transmit stored energy into joint movement, and transfer excess energy from the joint back to the attached muscles for dissipation [1]. They also act as mechanotransducers by transferring stress borne by the musculoskeleton to the...

collagen is the major protein component of cartilage, bone, skin and connective tissue and constitutes the major part of the extracellular matrix. collagen type i has complex structural hierarchy, which consists of treepolypeptide α-chains wound together in a rod-like helical structure. collagen is an important biomaterial, finding many applications in the field of tissue engineering. it has be...

the provision of an adequate quantity of cells with proper function and purity is one of the main challenges of tissue engineering studies. stem cells, with their self-renewal and differentiation capacity, are considered one of the main cell sources in the field of tissue engineering. previously, the use of chemical factors seemed to be the only possible way for stem cell differentiation. howev...

Nowadays, titanium-based alloys are among the most attractive metallic materials for biomedical applications (as implants) due to their non-biodegradability, low density, good mechanical properties as well as their good biocompatibility. Hydroxyapatite (Ca10 (PO4)6(OH)2, HA) has been widely used for biomedical applications due to its bioactive, biocompatible and osteoconductive properties. Firs...

BACKGROUND Previous studies suggest that mechanical feedback could coordinate morphogenetic events in embryos. Furthermore, embryonic tissues have complex structure and composition and undergo large deformations during morphogenesis. Hence we expect highly non-linear and loading-rate dependent tissue mechanical properties in embryos. METHODOLOGY/PRINCIPAL FINDINGS We used micro-aspiration to ...

Solvent-swollen polymer gels can be utilized as mechanical simulants of biological tissues to evaluate protective systems and assess injury mechanisms. However, a key challenge in this application of synthetic materials is mimicking the rate-dependent mechanical response of complex biological tissues. Here, we characterize the mechanical behavior of tissue simulant gel candidates comprising a c...