transforming growth factor beta (tgf-b) is a mediator released by nearly all cell types. it has suppression activity on the immune system, but exactly how this effect is carried out is not clear. previous experiments showed that igg interacts with or carriers active tgf-b, that could suppresses cytotoxic t-cell responses to an immunogenic tumor in mice. since t cell receptor (tcr) has structura...

conclusions p. gingivalis and p. intermedia could play a role in implant failure by changing the expression profiles of genes related to bone formation and resorption. results viability was reduced to 56.8% (p. gingivalis) and 52.75% (p. intermedia) at 1000 multiplicity. amongst 48 genes examined, expressions of bmper, smad1, il8 and nfrkb were found to be highly upregulated by both bacterial c...

conclusions the results of the present study showed that tgf-β1 (-509) c/t is strongly associated with quantitative parameters of connective tissue constituents of interdental papilla in cp patients. results the volume density (vʋ) of epithelium, connective tissue, collagenous and non-collagenous matrix and blood vessels had statistically significant differences between the control and chronic ...

conclusions tissue engineering may open a new window in cleft palate reconstruction. stem cells and growth factors play key roles in this field. results we reported a summary of the key-points concerning cleft palate development, the genes involving this defect, current therapeutic strategies, recently novel aspects, and future advances in treatments for easy and fast understanding of the conce...

introduction: transforming growth factor-beta 1 (tgf-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of ischemic stroke (is), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509c/t tgf-β1 gene polymorphism has been found to be assoc...

acute myeloblastic leukemia is the most frequent cancer in adults and the patients have a wide range of sub-classes. hla dr negative cases represent one of the major immune-phenotypic classes.  hla-dr is routinely used to distinguish acute promyelocytic leukemia (apl) from other aml subclasses based on the immunophenotype. the tgf-b signaling pathway, as a critical regulator, guides different v...

background: osteoarthritis is one of the most common diseases in middle‑aged populations in the world and could become the fourth principal cause of disability by the year 2020. one of the critical properties for cartilage tissue engineering (te) is the ability of scaffolds to closely mimic the extracellular matrix and bond to the host tissue. therefore, te has been presented as a technique to ...