background: successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. it has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. transforming growth factor beta (tgf-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. recent studies suggest a ...

Transforming growth factor (TGF)-β induces cell growth arrest in well-differentiated hepatocellular carcinoma (HCC) while hepatitis B virus X protein (HBx) minimizes the tumor suppression of TGF-β signaling in early chronic hepatitis B. However, how to reverse the oncogenic effect of HBx and sustain the tumor-suppressive action of TGF-β has yet to be investigated. The present study examined the...

In this article, we have reviewed current literature regarding the regulation of hepatocellular carcinoma (HCC) by the interaction of malignant hepatocytes and their tissue environment through cytokine signaling, here represented by transforming growth factor-beta (TGF-β) signaling. We have discussed responses of TGF-β signaling in transition of hepatic stellate cells to myofibroblasts (MFBs), ...

Abstract Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) suppressor mothers against decapentaplegic (Smad) receptors in high-grade tumors. Material Method Thirteen patients with a pathological diagnosis glioblastoma multiforme were included study. Pathological preparations eac...

Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine, secreted by a variety of cells including immune cells, tumor cells, and stromal cells. TGF-β signaling is dysregulated in cancer patients, and this aberrant signaling at least in part contributes to initiation and progression of many cancers including glioma. The dysregulated signaling components provide molecular targets for th...