Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation progression of cancer. The purpose this study was to retrospectively investigate expression mitochondrial tumor-suppressor DNA-repair proteins in patients oral squamous cell carcinoma (OSCC) evaluate relationship between their prognosis. We enrolled 197 OSCC who underwent surgical re...

The nuclear export protein chromosome maintenance region 1, found to be elevated in non-Hodgkin's lymphomas, controls localization of critical tumor suppressor proteins. Nuclear localization of tumor suppressor proteins is necessary for their cell surveillance function. However, their nuclear exclusion by chromosome maintenance region 1 renders them ineffective making this nuclear transporter a...

objective(s): stem cell differentiation into different cell lineages depends upon several factors, cell cycle control elements and intracellular signaling elements, including p15ink4b and p16ink4a genes. epigenetics may be regarded as a control mechanism which is affected by these factors with respect to their promoter structure.   materials and methods: the cd34 + cord blood stem cells were pu...

Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...

background: melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. various chemotherapeutic drugs such as 5-fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. objective: to assess whether multiple ...

Background: The potential of plants, as a safe and eukaryotic system, is considered in the production of recombinant therapeutic human protein today; but the expression level of heterologous proteins is limited by the post-transcriptional gene silencing (PTGS) response in this new technology. The use of viral suppressors of gene silencing can prevent PTGS and improve transient expression level ...

Abstract Mdm2 and MdmX are two closely related proteins that have been well-characterized as negative regulators of the tumor suppressor p53. Their interplay especially respective roles in ubiquitination subsequent degradation p53 lacked clarity. Yang colleagues now demonstrate an obligate role for recruitment E2 ubiquitin ligase UbcH5c to Mdm2-MdmX hetero-oligomer. The use elegant genetically ...