OBJECTIVE To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors. METHODS Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n=...

Aims: Testing ultrasound-mediated cavitation for enhanced delivery of the therapeutic antibody cetuximab to tumors in a mouse model. Methods: Tumors with strong EGF receptor expression were grown bilaterally. Cetuximab was coadministered intravenously nuclei, consisting either ultrasound contrast agent Sonovue or gas-stabilizing nanoscale SonoTran Particles. One two exposed focused ultrasound. ...

Mouse IgG2a monoclonal antibodies with specific binding reactivity in vitro to human tumors of the gastrointestinal tract were radioiodinated and injected into immunosuppressed mice xenografted with human colon carcinoma tumors. The antibodies preferentially localized in tumor tissue compared to normal mouse tissue, as determined by differential tissue counting of radioactivity. Preferential an...

Sialylations are post-translational modifications of proteins and lipids that play important roles in many cellular events, including cell-cell interactions, proliferation, migration. Tumor cells express high levels sialic acid (SA), which often associated with the increased invasive potential clinical tumors, correlating poor prognosis. To overcome lack natural SA-receptors, such as antibodies...

widespread studies on tumor diagnosis has led to the development of techniques with greater sensitivity and improved specificity for detection of occult and small subclinical tumors. tumor imaging by radiolabeling of tumor-specific antibodies (immunoscintigraphy) or tissue specific biochemical agents (receptor imaging) and especially physiologic imaging with positron emitters (pet), have opened...

Monoclonal antibodies to different markers can facilitate the diagnosis of T and B cell lymphomas, histiocytic lymphomas, malignant histiocytosis, and Hodgkin's disease. The B-cell lymphomas can be identified specifically by monoclonal anti-idiotype antibodies. Monoclonal antibodies are produced to defined markers like carcinoembryonic antigen (CEA) in colon carcinomas and other antigens especi...

Receptor disorders may produce specific clinical manifestations resembling hypo-or hyper-function of related endocrine gland. Receptor disorders can be divided into five categories: 1)Altered receptor concentration exists in insulin resistance seen in obsity, familial hypercholes­terolemia and in testicular feminization. 2) Altered receptor affinity can be seen in fasted obese patients, acromeg...

The immunologic defense mechanism is well demon­trated in neoplasia of animals and human. Spontaneous regression of many human tumors such as malignant melanomas, 1vmphosarcomas, neuroblastomas choriocar­cinomas, adenocarcinomas and leukemias is due to the defense mechanism of lymphoretrcular system. The discovery of carcinoembrvonicantigen in carcinoma of gastrointestinal tract and the alpha-f...

background: animal suitable models are very useful tools in the studies of complicated diseases. in this way we can study the heterogeneity of human genome and also we can minimize the effect of environmental factors in the incidence of cancers. in this study the expression of vwf and pcna in tumors was determined by immunohistochemistry and also we measured three cancer markers and two blood f...