In previous chapters we analyzed data from so-called one-way experimental designs, in which subjects were randomly assigned to groups that di↵ered on a single treatment or grouping variable. In this chapter we will analyze data from factorial experiments. Factorial experiments contain two or more experimental variables. In a completely crossed factorial experiment, each level of every variable ...

In previous chapters we analyzed data from so-called one-way experimental designs, in which subjects were randomly assigned to groups that di↵ered on a single treatment or grouping variable. In this chapter we will analyze data from factorial experiments. Factorial experiments contain two or more experimental variables. In a completely crossed factorial experiment, each level of every variable ...

Herpes simplex virus type 1 (HSV-1) is known to cause diseases of various severities. There is increasing interest to find drug combinations to treat HSV-1 by reducing drug resistance and cytotoxicity. Drug combinations offer potentially higher efficacy and lower individual drug dosage. In this paper, we report a new application of fractional factorial designs to investigate a biological system...

Information in a statistical experiment is often measured through the determinant of its information matrix. Under first order normal linear models, the determinant of the information matrix of a two-level factorial experiment neither depends on where the experiment is centered, nor on how it is oriented, and balanced allocations are more informative than unbalanced ones with the same number of...