Significant degenerative changes were observed in the kidney tissue of untreated neonatal streptozotocin (n0STZ)-induced type-II diabetic rats. These degenerative changes were diminished in the kidney tissue of diabetic animals given glibenclamide and Aloe leaf gel and pulp extracts. Kidney lipid peroxidation levels were increased in diabetic rats compared to healthy rats; these levels were hig...

Sulfonylureas, widely used as hypoglycemic agents in adults with type 2 diabetes, have neuroprotective effects preclinical models of central nervous system injury, and children neuropsychomotor impairments linked to neonatal diabetes secondary ATP-sensitive potassium channel mutations. In the human rodent retina, we show that glibenclamide-activated sulfonylurea receptor 1 (SUR1) is expressed r...

objective: the aim of the present study was to investigate the prevalence of hypertension and type ii diabetes in elderly iranianresidents of the kahrizak charity foundation(kcf). materials and methods: in this cross-sectional study, a total of two hundred sixty eight men and women ≥60 years were studied. the data were collected during annual health examination of the elderly residents in kcf. ...

background: diabetic nephropathy is considered to be the most common cause of end stage renal disease (esrd). proteinuria is declared as the most marked risk factor in progression towards esrd. the aim of this study was to evaluate the efficacy of pentoxifylline for reduction of proteinuria in type ii diabetic patients. methods: from may 2007 to june 2008, this randomized clinical trial study w...

background: visfatin is a new adipocytokine which is largely secreted by visceral adipose tissue and its effects in the development of diabetes and inflammatory reactions are similar to insulin. it acts synergistically with insulin in increasing glucose cellular uptake, stimulating glucose transfer to the muscle and adipose tissue, as well as in preventing hepatic glucose production. its insuli...

abstract        background and objective: osteoporosis is one of the complications of diabetes. the aim of this study was to determine the impact of resistance training along with portulaca oleracea supplementation on opg and nfκb levels (bone markers) in women with type ii diabetes.        methods: overall, 28 women with type ii diabetes (44 to 60 years old) were randomly and equally assigned ...

Aims : The present study evaluates the antidiabetic activity of Swertia chirata (aqueous extract) on the blood glucose level of streptozotocin induced diabetic rat models. Objectives : i) To study the antidiabetic activity of aqueous extract of Swertia chirata in streptozotocin induced diabetes in albino rats. ii) To compare the antidiabetic activity of Swertia chirata extracts with that of sta...

OBJECTIVE Diabetes mellitus is a syndrome of multiple etiologies. Both type 1 and type 2 diabetes lead to multiple abnormalities of lipid and lipoprotein metabolism. The aim of this investigation was to study the influence of fenofibrate on the blood glucose lowering effect of glibenclamide. MATERIALS AND METHODS Glibenclamide (0.45, 0.23 mg/kg) and fenofibrate (18.1, 9.38 mg/kg) was treated ...