Background: Due to high differentiation potential and self-renewality, Mesenchymal Stem Cells are now widely considered by researchers in several diseases. FBS is used as a supplement in culture media for proliferation, differentiation, and other culture processes of MSCs, which is associated with transmission risk of a variety of infections as well as immune responses. PRGF derived from platel...

heart failure is one of the leading causes of death worldwide. end stage disease often requires heart transplantation, which is hampered by donor organ shortage. tissue engineering represents a promising alternative approach for cardiac repair. for the generation of artificial heart muscle tissue several cell types, scaffold materials and bioreactor designs are under investigation. in this revi...

Objective(s): Umbilical cord blood is a good source of the mesenchymal stem cells that can be banked, expanded and used in regenerative medicine.  The objective of this study was to test whether amniotic membrane extract, as a rich source of growth factors such as basic-fibroblast growth factor, can promote the proliferation potential of the umbilical cord mesenchymal stem cells. Materials and ...

Background: The application of mesenchymal stem cells in the healing of chronic wounds is one of the most challenging issues in cell therapy. The present study investigated the efficacy of intradermal injection of umbilical cord Wharton's Jelly-derived mesenchymal stem cells in diabetic wound healing using ultrasound imaging in an animal model. Methods: During this experimental laboratory stud...

new blood forming vessels are produced by differentiation of mesodermal precursor cells to angioblasts that become endothelial cells (ecs) which in turn give rise to primitive capillary network. human cord blood (hcb) contains large subsets of mononuclear cells (mncs) that can be differentiated into endothelial-like cells in vitro. human mononuclear progenitor cells were purified from fresh umb...

New blood forming vessels are produced by differentiation of mesodermal precursor cells to angioblasts that become endothelial cells (ECs) which in turn give rise to primitive capillary network. Human cord blood (HCB) contains large subsets of mononuclear cells (MNCs) that can be differentiated into endothelial-like cells in vitro. Human mononuclear progenitor cells were purified from fresh umb...

Adult stem cells have generated great amount of interest amongst the scientific community for their potential therapeutic applications for unmet medical needs. We have demonstrated the plasticity of mesenchymal stem cells isolated from the umbilical cord matrix. Their immunological profile makes it even more interesting. We have demonstrated that the umbilical cord is an inexhaustible source of...

Submit Manuscript | http://medcraveonline.com Abbreviations: UCB-SCs: Umbilical Cord Blood-Derived Stem Cells; HSCs: Hematopoietic Stem Cells; MSCs: Mesenchymal Stem Cells; UCB-MSCs: Umbilical Cord Blood-derived Mesenchymal Stem Cells; UCB-MSCs: Umbilical Cord Blood-derived MSCs; hUCB-MSCs: Human Umbilical Cord Blood-derived MSCs; GvHD: Graft-versus-Host Disease; HIV: Human Immunodeficiency Virus.

background: stem cell therapy for the treatment of vascular-related diseases through functional revascularization is one of the most important research areas in tissue engineering. the aim of this study was to investigate the in vitro differentiation of umbilical cl-msc into endothelial lineage cells. methods: in this study, isolated cells were characterized for expression of msc-specific marke...

objective(s): the present day challenge is how to obtain germ cells from stem cells to treat patients with cancer and infertility. much more efforts have been made to develop a procedure for attaining germ cells in vitro. recently, human umbilical cord-derived mesenchymal stem cells (humscs) have been introduced with higher efficacy for differentiation. in this work, we tried to explore the eff...