INTRODUCTION The use of opioids is associated with various adverse effects, including the development of dependence, tolerance, addiction and opioid-induced hyperalgesia (OIH).(1,2) Recently, there has been a marked increase in the number of basic and clinical science literature exploring the mechanisms and clinical significance of OIH. Broadly, OIH refers to an increased sensitivity to pain as...

iranian historical houses constitute a significant part of the architectural heritage of the country both qualitatively and quantitatively though due research is not conducted on them. this study investigates t0he physical evolution of qajar house of baqeri in gorganand attempts to monitor life stream over its lifespan. the study also investigates the effect of external transformations on archi...

the prognosis of the neoplastic diseases depends not only on the biogenetic characteristics of cancer cells but also on the immunological response of patients, which may influence the biological features of cancer cells themselves as well as the angiogenic processes. moreover, the immune system in vivo is under a physiological psychoneuroendocrine (pne) regulation, mainly mediated by the brain ...

Two scenarios of neuronal evolution (monophyly and polyphyly) are discussed in the historical timeline starting from the 19th century. The recent genomic studies on Ctenophores re-initiated a broad interest in the hypotheses of independent origins of neurons. However, even earlier work on ctenophores suggested that their nervous systems are unique in many aspects of their organization and a pos...

in order to understand the unknown parts of history, having access to new historical documents and their interrelationship could be a breakthrough for researchers in the field of history. in this context, coins and numismatic knowledge are known as valuable resources to clarify the historical uncertainties such as geographical names and their evolution, discovering unknown cities, their names, ...