The complex [PtCl 2 (cyclohexane-1 R ,2 -diamine)] has been combined in a Pt(IV) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA , and potential antimetastatic...

Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. It is extensively metabolized in liver, representing β -oxidation in the mitochondria one of its main metabolic route (40%). Carnitine is responsible for its entry into the mitochond...

Valproic acid is one of the most commonly used anti-epileptics in the treatment of childhood epilepsy. The aim of this study was to determine the risk factors for and incidence of subclinical hypothyroidism (SH) in children with idiopathic epilepsy using valproic acid (VPA). Patients monitored with a diagnosis of idiopathic epilepsy, using valproic acid for longer than 12 months and who were se...

introduction: chemokine receptors are found on the surface of stem cells. there have been 19 distinct chemokine receptors described in mammals. chemokines are major players in migration and homing. therefore, changes in their levels or function can help us to increase the migratory potential of these cells. valproic acid differs in structure from other drugs in common use. the way in which valp...

background:   valproic acid (vpa) is used to be an effective anti-epileptic drug and mood stabilizer. it has recently been demonstrated that vpa could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. in the present research we demonstrate the effect of vpa on peripheral nerve r...

AIM To investigate the relationship between the newly discovered adipocytokines and increasing body weight (paralleled by increased insulin resistance), and antiepileptic drug therapy with valproic acid (VPA). DESIGN AND METHODS 44 children with idiopathic, generalized epilepsy treated with valproic acid (VPA), and 40 control group children were included in this study. RESULTS Both the VPA-...

Objective(s) As there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (VPA), this study was conducted to investigate the relationship between patient demographic characteristics, VPA dosage and the drug clearance in adult Iranian patients. Materials and Methods Patients (N= 47) were either on monotherapy with VPA or were under co...

Background:   Valproic acid (VPA) is used to be an effective anti-epileptic drug and mood stabilizer. It has recently been demonstrated that VPA could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. In the present research we demonstrate the effect of VPA on peripheral nerve r...

Background: As a novel pro-apoptotic kinase, Mammalian sterile 20–like kinase 1 (Mst1) promotes programmed cell death in animal models of inflammatory diseases. This research aimed to determine the level of expression of Mst1 gene in a rat model of spinal cord injury (SCI) treated with valproic acid (VPA). Methods: Animals were divided into four groups: Contused animals (untreated); laminectom...