PURPOSE The present study, was aimed to assess the cytotoxic effects of Ornithogalum cuspidatum methanolic fractions on PC-3, prostate cancer cells and WEHI-164, Fibrosarcoma cells. METHODS Methanolic fractions of O. cuspidatum were prepared using solid phase extraction and the cells were treated with different concentrations for 12 and 24 hours. Cytotoxicity and cell viability were measured ...

The water extract of Indonesian tea mistletoe, Scurrula oortiana ('benalu teh'), has been used for generations to treat tumours, however, little is known of its biological action. In the present study the stem and leaf extracts of S. oortiana were investigated for their modulation of tumour cell sensitivity toward TNFalpha, a potent anti-tumour cytokine. WEHI-164 cells which are known to be sen...

Electrochemotherapy (ECT) with bleomycin has been effectively used in recent years to treat various skin tumors. Microsecond electric pulses significantly improve (BLM) delivery and its anticancer potential. Up now, we can determine field distribution the targeted tissue, however, of injected drug is still not well known. In this study, propose combination indocyanine green (ICG) as a practical...

The amino boronic dipeptide, PT-100 (Val-boro-Pro), a dipeptidyl peptidase (DPP) inhibitor, has been shown to up-regulate gene expression of certain cytokines in hematopoietic tissue via a high-affinity interaction, which appears to involve fibroblast activation protein. Because fibroblast activation protein is also expressed in stroma of lymphoid tissue and tumors, the effect of PT-100 on tumo...

OBJECTIVES Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. Chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery since it is biodegradable, biocompatible and non-allergenic polysaccharide. The objective of the pr...