Objective: We examined whether chronic leptin treatment of diet-induced obese (DIO) rats promotes or alleviates the susceptibility to continued high-fat (HF) feeding. Secondly, we examined if voluntary wheel running (WR) is beneficial in reducing the trajectory of weight gain in HF-raised leptin resistant rats. Research Design and Methods: Sprague-Dawley rats were chow or HF fed for five months...

The present study compared the intravenous glucose tolerance test (IVGTT) and the glucose postprandial response (GPPR) test for the evaluation of glucose metabolism in obese dogs. A total of ten owned obese dogs (body condition score (BCS) of 9; fat mass, 45.7 (sem 1.51) %) were used. These dogs had their weight reduced by 20 % (BCS, 8; fat mass, 33.5 (SEM 1.92) %; P < 0.001), designated as wei...

BACKGROUND/PURPOSE In gastroschisis it is proposed that gut reduction may be achieved without intubation or general anesthesia (GA) through ward reduction. The authors aimed to determine if ward reduction decreased morbidity and duration of treatment. METHODS Infants born from January 1, 1995, to December 31, 2001, with gastroschisis were managed with either reduction under GA in the operatin...

Initial successful weight loss is often followed by weight regain after the dietary intervention. Compared with lean people, cellular stress in adipose tissue is increased in obese subjects. However, the relation between cellular stress and the risk for weight regain after weight loss is unclear. Therefore, we determined the expression levels of stress proteins during weight loss and weight mai...

Background: Weight regain (WR) after bariatric surgery is common. Several factors involved in WR have been identified, but there has little research on specific eating habits such as snacks rather than regular meals and being a “sweet-eater”.

We studied the effect in vitro of various concentrations of Triton WR-1339 on normolipidemic canine plasma and on the high density lipoproteins (HDL) isolated from this plasma by ultracentrifugation. As a preamble to this study, we established that Triton WR-1339 has a unimer molecular weight of 4,500, a micellar molecular weight of 180,000, and a critical micellar concentration (CMC) of 0.018 ...

We developed a standard weight equation Ws to aid in the analysis of pejerrey Odonthestes bonariensis body condition over time and across populations using the relative weight index Wr. Weight--length data were compiled from 73 populations of pejerrey (N=16.022) from the Argentine pampas region. We used the regression-line-percentile technique, which provides a 75th-percentile standard by lengt...

The level of the transcription factor Nanog directly determines the efficiency of mouse embryonic stem cell self-renewal. Nanog protein exists as a dimer with the dimerization domain composed of a simple repeat region in which every fifth residue is a tryptophan, the tryptophan repeat (WR). Although WR is necessary to enable Nanog to confer LIF-independent self-renewal, the mechanism of dimeriz...