We have recently shown that subdiaphragmatic vagotomy enhances bradykinin-induced hyperalgesic behavior and decreases baseline paw withdrawal threshold to mechanical stimulation of the hindpaw skin in rats by a peripheral mechanism. To elucidate the underlying mechanism, we studied whether lesions of efferent neuroendocrine pathways could prevent or reverse the potentiating effect of vagotomy. ...

Fast-conducting myelinated high-threshold mechanoreceptors (AHTMR) are largely thought to transmit acute nociception from the periphery. However, their roles in normal withdrawal and in nerve injury-induced hyperalgesia are less well accepted. Modulation of this subpopulation of peripheral neurons would help define their roles in withdrawal behaviors. The optically active proton pump, ArchT, wa...

objective: several studies have shown that, although transplantation of neural stem cells into the contusion model of spinal cord injury (sci) promotes locomotor function and improves functional recovery, it induces a painful response, allodynia. different studies indicate that bone marrow stromal cells (bmscs) and schwann cells (scs) can improve locomotor recovery when transplanted into the in...

objective(s): as heat, pain is one of the most common clinical symptoms. generally, calcitonin (ct) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. however, the detailed mechanism remains unknown.materials and methods: in this study, chronic constriction injury (cci) rat model was created, and ho...

BACKGROUND NR2B subunits (NMDA receptor 2B subunit) play an important role in generation of pain and forming central sensitization of pain. Ro 25-6981, a highly selective NR2B antagonist, gained much attention in recent years. In this study, we used a rat model of incisional pain to investigate effects of postoperative analgesia and changes of postoperative hyperalgesia induced by remifentanil ...

Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and ho...

Background. Injections of acidic saline into the gastrocnemius muscle in rats produce a bilateral long-lasting hyperalgesia similar to fibromyalgia in humans. No previous study investigated the effect of electroacupuncture (EA) on this acidic saline model. This study aimed to identify the effects of EA in the hyperalgesia produced by repeated intramuscular injections of acidic saline. Methods. ...

BACKGROUND Lysophosphatidic acid receptor 1 and Rho/ROCK signaling is implicated in bone cancer pain development. However, it remains unknown whether the two signaling pathways function together in P2X3 receptor-mediated bone cancer pain. RESULTS In this study, using a rat model of bone cancer, we examined the expression of P2X3 and lysophosphatidic acid receptor 1 in rat dorsal root ganglion...

Introduction: As sex differences have been observed repeatedly in chronic pain, it is likely that the gonadal hormones are responsible for these differences. To investigate the responsible mechanism for chronic pain different models have been created. This study is examining the effects of gonadal hormones on nociceptive responses of the rats in CCI (chronic constriction injury) and SNI (spread...