نتایج جستجو برای: withdrawal threshold test
تعداد نتایج: 945249 فیلتر نتایج به سال:
پیش زمینه و هدف: امروزه پیوند سلول های بنیادی از روش های متداول برای درمان ضایعات نخاعی (sci) به شمار می رود. مطالعات نشان داده اند که پیوند سلول های بنیادی عصبی (nscs) برای درمان sci علیرغم ایجاد بهبود حرکتی موجب ایجاد دردهای نوروپاتیک می شود. از آنجا که سلول های بنیادی مغز استخوان (bmscs) کاربرد فراوانی در درمان sci دارند لذا هدف از مطالعه حاضر بررسی تأثیر پیوند سلول های مذکور در ایجاد دردها...
BACKGROUND Natural products including Agrimonia eupatoria are considered an incomparable source of molecular diversity that has led to the medicines, especially for pain treatment. To investigate the antinociception of Agrimonia eupatoria, we examined its activity in a rat model of cisplatin neuropathy. MATERIALS AND METHODS Male Sprague-Dawley rats received intraperitoneal (i.p.) cisplatin t...
Background & Aims: Many evidences show that regular resistance exercise training can increase activity and release of opioids in the CNS. Also it is known that as the body needs magnesium sulfate antagonist of N-methyl-D-aspartate receptor as a pain reliever, it increases resistance exercise. In this research, the effect of resistance exercise and oral magnesium sulfate on pain threshold o...
Background & Aims: Nowadays stem cell therapy is the common methods for treatment of spinal cord injury (SCI). Studies have shown that although transplantation of Neural Stem Cells (NSCs) in injured spinal cord promotes motor function but leads to development of neuropathic pain (NP). Since bone marrow stromal cells (BMSCs) are commonly used in treatment of SCI, we sought to investigate whether...
Spinal cord injury (SCI) impairs sensory systems causing allodynia. To identify cellular and molecular causes of allodynia, sensitive and valid sensory testing in rat SCI models is needed. However, until recently, no single testing approach had been validated for SCI so that standardized methods have not been implemented across labs. Additionally, available testing methods could not be implemen...
OBJECTIVE To assess the effect of high-voltage cathodic current on pain from a sciatica experimental model. METHODS A total of 16 male Wistar rats were submitted to the sciatica experimental model in the right hind paw. They were divided into sham group (GS) and group treated with cathodic current (GP-) for 20 min/daily, for 10 days). The model of sciatic compression was performed with a 4.0-...
Background: Many evidences have shown that aerobic exercise can alter the function and release certain neurotransmitters such as opioids in the brain. In this research, the effect of endurance exercise (running on a treadmill for six weeks) and oral magnesium sulphate on pain threshold of addicted rats following withdrawal syndrome was investigated. Methods: In this study male wistar rats we...
The selective mu-opioid agonist, D-Ala2,N-Me-Phe4,Gly5-ol-enkephalin (DAMGO), or the selective A1-adenosine agonist N6-cyclopentyladenosine (CPA), when coinjected intradermally with prostaglandin E2 (PGE2), dose-dependently inhibited PGE2-induced mechanical hyperalgesia in the rat hindpaw, as determined by the Randall-Selitto paw-withdrawal test. Repeated (hourly x 3) intradermal injections of ...
In this study, the response of female rats in different phases of the estrus cycle to nociceptive stimulation was evaluated using thermal (hot plate and tail immersion) and chemical (formalin) tests. In the hot plate test, the paw licking latency fell significantly (p < 0.05) in the metestrus and diestrus phases compared with the proestrus and estrus phases. The observations in the tail immersi...
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