نتایج جستجو برای: wnt pathway
تعداد نتایج: 325509 فیلتر نتایج به سال:
Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...
Background and Aim: Chronic myeloid leukemia (CML) is a myeloprolifrative neoplasm that is characterized by an expansion of myeloid, erythroid cells and platelets in peripheral blood and myeloid hyperplasia in bone marrow. Secreted frizzled-related protein family is a negative regulator of the Wnt signaling pathway that suppresses this signaling pathway in healthy individuals. Aberrant regulati...
Objective(s): To investigate and test the hypotheses that TGF-β1 enhanced myocardial differentiation through Wnt/β-catenin pathway with rat bone marrow mesenchymal stem cells (BMSCs).Materials and Methods: Lentiviral vectors carrying the TGF-β1 gene were transduced into rat BMSCs firstly. Then several kinds of experimental methods were u...
Background & Aims: Triple-negative breast cancer cells refer to any breast cancer that does not express the genes for the estrogen, progesterone, and HER2 receptors. The Wnt signaling pathway is important in the development and progression of various types of cancers. Quinacrine, a derivative of 9-aminoacridine, has been shown to inhibit the growth of several types of cancer cells. In this stud...
objective: osteoblasts arise from multipotent mesenchymal stem cells (mscs) present in the bone marrow stroma and undergo further differentiation to osteocytes or bone cells. many factors such as proteins present in the wnt signaling pathway affect osteoblast differentiation. ror2 is an orphan tyrosine kinase receptor that acts as a co-receptor in the non-canonical wnt signaling pathway. howeve...
Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
Micro-vascular complications such as diabetic nephropathy (DN) develop in patients with uncontrolled T1DM. Low density lipoprotein receptor-related protein 5 (LRP5) is the co-receptor ligand of Wnt signaling pathway. Many single nucleotide variants have been identified human LRP5 gene and were reported to be associated metabolic disorders. The Wnt/β-catenin pathway has proposed play an importan...
The goal of this study is to better understand the complexity canonical Wnt/β-catenin (C-WNT) signaling pathway in colorectal cancer (CRC): how it works, its key mutations and novel therapeutic compounds under development. PubMed, Scopus SciELO were used find most relevant medical literature on issue. C-WNT regulates essential cellular biological processes: genetic changes are significant contr...
Background: Atrophy in skeletal muscle plays an important role in disease-related tissue dysfunction such as sarcopenia. The Wnt-signaling pathway has been shown to be critical for skeletal muscle development. Current evidence suggests that exercise trainings may alter hypertrophy-related signaling in skeletal muscle. Therefore, the purpose of this study was investigating the effect of three mo...
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