The odontoblastic differentiation of dental pulp stem cells (DPSCs) associated with caries injury happens in an inflammatory context. We recently demonstrated that there is a link between inflammation and tissue regeneration, identified via enhanced DPSC-mediated dentinogenesis vitro. Brain-derived neurotrophic factor (BDNF) nerve growth factor-related gene family molecule which functions throu...

brain derived neurotrophic factor (bdnf) is a neurotrophin acting at several levels in the brain. additionally, bdnf was shown to be responsible for the survival, maintenance and growth of neurons. also, bdnf plays an important role in synaptic plasticity and memory processes. in activity-dependent synaptic plasticity, bdnf enhances long-term potentiation (ltp) in the hippocampus but blocks the...

BACKGROUND The human Val66Met polymorphism in brain-derived neurotrophic factor (BDNF), a key factor in neuroplasticity, synaptic function, and cognition, has been implicated in the pathophysiology of neuropsychiatric and neurodegenerative disorders. BDNF is encoded by multiple transcripts with distinct regulation and localization, but the impact of the Val66Met polymorphism on BDNF regulation ...

Depression is a complex psychiatric disorder that significantly impacts millions of individuals worldwide. Despite advances in our understanding its neurobiological underpinnings, treatment options remain limited, and not all patients respond adequately to available therapies. Emerging evidence has implicated brain-derived neurotrophic factor (BDNF), critical regulator neuronal plasticity, the ...

Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and cardiovascular development and function. Recently, a common single nucleotide polymorphism in the bdnf gene, resulting in a valine to methionine substitution in the prodomain (BDNF(Met)), has been shown to lead to memory impairment and susceptibility to neuropsychiatric disorders in humans heterozygous for the ...