Androgen receptor (AR)-mediated pathways play a critical role in the development and progression of prostate cancer. However, little is known about the regulation of AR mRNA stability and translation, two central processes that control AR expression. The ErbB3 binding protein 1 (EBP1), an AR corepressor, negatively regulates crosstalk between ErbB3 ligand heregulin (HRG)-triggered signaling and...

Androgen receptor (AR)-mediated signaling is necessary for prostate cancer cell proliferation and an important target for therapeutic drug development. Canonically, AR signals through a genomic or transcriptional pathway, involving the translocation of androgen-bound AR to the nucleus, its binding to cognate androgen response elements on promoter, with ensuing modulation of target gene expressi...

The androgen receptor (AR) poly-glutamine polymorphism (AR-Q) was reported to play role in endometrial cancer (EMCA) development, yet controversial. Environmental factors interact with genetic variation have been reported in EMCA. Aerosol toxins, polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP), are EMCA facilitators. This report examined the interplay between AR-Qs and BaP in EMCA. During ...

Female mice lacking AR display alterations in ovarian and uterine function. However, the biology of AR in the fallopian tube is not fully understood. To gain an insight into potential roles of AR in this tissue, we demonstrated that eCG treatment increased AR expression in a time-dependent manner and subsequent treatment with hCG decreased AR expression in mouse fallopian tubes. This expression...

Amphiregulin (AR) is a newly discovered glycosylated, 84-amino acid residue polypeptide growth regulator which has sequence homology to the EGF family of proteins. To obtain immunological reagents to study the biological role of AR, two synthetic peptides containing sequences corresponding to distinct regions of AR were used to generate polyclonal antibodies in rabbits. One preparation of antip...

De e enm nm nm nm nm nm nmar ar ar ar ar ar ark k k k k k k gy, Abstract Background—Patients with severe tricuspid regurgitation (TR) frequently present with

The cross-section of the thermal neutron capture 41 Ar(n,γ) 42 Ar( t 1/2 =32.9 y) reaction was measured by irradiating a 40 Ar sample at high-flux reactor Institut Laue-Langevin (ILL) Grenoble, France. signature two-neutron has been observed measuring growth curve and identifying 1524.6 keV γ-lines shorter-lived K(12.4 h) β − daughter Ar. Our preliminary value cross section is 240(80) mb 25.3 m...

Background: The presence of even a very small quantity of dye in water bodies is undesirable and affects the water bodies. Dye removal from industrial waste water is significant; hence in this study, a material that is an economical waste product was employed to test its acid dye removing capacity from aqueous solution. Methods: In this study, batch mode experiments were performed in the sorpt...