A reversed-phase liquid chromatographic method for the determination of 1,7,7-trimethyl-bicyclo(2,2,1)heptan-2-one in a cream formulation is developed and validated. The separation was achieved using an isocratic mobile phase, on a Lichrosorb C8 column. The calibration curve is linear (r(2)= 0.9999) from 25-175% of the analytical concentration of 1.0 mg/ml. The mean percent standard deviation v...

Imiquimod is an immunomodulator with both antitumor and antiviral properties. It is currently available in two cream formulations as Aldara (imiquimod 5%) and the newly approved Zyclara (imiquimod 3.75%). Imiquimod has been associated with localized erythema, crusting, and scaling at the site of application. However, more severe generalized skin eruptions including erythema multiforme, psoriasi...

Thrombophlebitis is a common complication of intravenous therapy with incidence of 24% to 29% (3, 6), which is rarely serious but the pain is often vc-ry bothersome (I). To minimise infusion phlebitis, various measures have been suggested (6). Woodhouse (8) used 'Movelat cream', as a preventive measure, containing I% adrenocortical extract, 0.2'" organoheparinoid, 22% salicylic acid in cream ba...

A 34-year-old woman developed nephrotic syndrome after using a skin lightening cream that contained an extremely high level of mercury. Blood and urine mercury levels were elevated and a renal biopsy revealed minimal change disease. Membranous nephropathy was excluded using immunofluorescence and electron microscopy. Her proteinuria remitted 9 months after she stopped using the cosmetic cream. ...

Consider the following scenario: Every day before work, you stop at a neighborhood coffee shop and order a cup of coffee with cream and no sugar. This scenario repeats itself for years without incident. Then one day, after you drive away with your coffee, you notice that the workers forgot the cream and put in sugar instead. The next day you mention the mistake, and the coffee shop manager apol...

BACKGROUND Herpes simplex virus infection (HSV) is a common and ubiquitous infection of the skin which causes mucocutaneous lesions called cold sores (herpes labialis) or fever blisters. It is estimated that approximately 80% of the population worldwide are carriers of the Herpes simplex virus, approximately 40% suffer from recurrent recurrent infections. This study evaluates the in vitro skin ...

Here, we investigated the mechanism of the antihyperalgesic effect of capsaicin cream in the nerve injury-induced neuropathic pain model in mice. In naive mice, application of capsaicin cream onto footpad caused no significant changes in the thermal latency in contrast to the severe thermal hyperalgesia induced by a capsaicin ointment. On the other hand, application of the cream 3 h before test...

OBJECTIVES High consumption of bakery products such as cream-filled pastries may cause serious health risks and food poisoning to humans. Therefore, investigation of the microbial and chemical qualities of bakery products containing cream is necessary. The purpose of the present study was to investigate the chemical qualities and microbial contaminations of cream-filled pastries collected from ...