OBJECTIVES Protease inhibitors are one of the most promising and investigated subjects for their role in pharmacognostical and pharmacological studies. This study aimed to investigate antineoplastic and antioxidant activity of trypsin inhibitors (TIs) isolated from three plant sources and their inhibitory role in the cell line. MATERIALS AND METHODOLOGY TIs were obtained from different plant ...

Farnesyltransferase (FTase) inhibitors (FTI) have broad antineoplastic actions targeting both cancer cells and mesenchymal cells involved in tumor angiogenesis. The small GTPases H-Ras, Rheb, and RhoB and the centromere proteins CENP-E and CENP-F are relevant targets of farnesylation inhibition; however, their relative importance in the antineoplastic effect of FTIs may vary in different cell t...

1,25-Dihydroxyvitamin D (calcitriol), the most active metabolite of vitamin D, has significant antineoplastic activity in preclinical models. Several mechanisms of activity have been proposed. These include inhibition of proliferation associated with cell cycle arrest and, in some models, differentiation, reduction in invasiveness and angiogenesis, and induction of apoptosis. Proposed mechanism...

Medicinal plants have duly been implicated in the development of typical antineoplastic agents. Here, medicinal plant under discourse, Trichosanthes dioica Roxb., commonly known as Pointed gourd English, Potol Bengali, is a climber vine found wild and cultivated all over plains India its neighbouring countries for fruits, consumed favoured vegetable. The present work attempts to assemble critic...

76. Connor TH, Anderson RW, Sessink PJ et al. Effective-ness of a closed-system device in containing surface contamination with cyclophosphamide and ifosfamidein an i.v. admixture area. Am J Health-Syst Pharm. 2002; 59:68–72.77. Vandenbroucke J, Robays H. How to protect environ-ment and employees against cytotoxic agents: the UZGent experience. J Oncol Pharm Pract. 2001;...

The aim was to research the pharmacotherapy of psoriasis with antiphospholipid syndrome based on ABC/VEN analysis antiviral drugs. materials study were clinical and pharmacological groups for background syndrome. Regulatory, documentary, marketing, pharmacoeconomic, methods used. Studied most drugs INN basic have diagnostic codes ATC classification L "Antineoplastic immunomodulatory agents" cod...

Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We exa...

Platinum drugs remain the backbone of many antineoplastic regimens. Among the numerous chemical or pharmacological effects of platinum drugs, some aspects tend to be under-reported. Thus, this perspective paper intends to stress some neglected properties of platinum drugs: first, the physico-chemical characteristics (aquation reaction kinetics) that determine site-specific toxicity; second, the...