Previous inhalation toxicity studies from our laboratory have shown that 1,1-dichloroethylene (1,1-DCE), 1,1-dibromoethylene (1,1-DBE), and 2-chloro-1,3,-butadiene (2-CBD) are more toxic to fasted rats than to fed rats. Vinyl chloride monomer (VCM) and 1,1-difluoroethylene (1,1-DFE) were not acutely hepatotoxic at 46,500 and 82,000 ppm, respectively, in normal male rats, whether fed or fasted. ...

Early studies reveal that testicular orphan nuclear receptor 4 (TR4) modulates signaling pathways that control various cell functions. However, how TR4 activity is regulated without the involvement of specific ligand(s) remains unclear. Here we identify a daf-16 family protein-binding element (DBE; 5'-TGTTTAC-3') in the TR4 promoter that can be recognized by the forkhead transcriptional factor ...

Myeloperoxidase. H,O,, and a halide form a potent antimicrobial system which is operative in the polymorphonuclear leukocyte (PMN). The formation of singlet oxygen (‘0,) by this system is suggested by (a) the conversion of 2,5diphenylfuran to its specific singlet oxygen product cisdibenzoylethylene (cis-DBE); (b) the inhibition of this reaction by the ‘0, quenchers p-carotene, bilirubin, histid...

The proapoptotic protein Noxa, a member of the BH3-only Bcl-2 protein family, can effectively induce apoptosis in cancer cells, although the relevant regulatory pathways have been obscure. Previous studies of the cytotoxic effects of a-tocopheryl succinate (a-TOS) on cancer cells identified a mechanism whereby a-TOS caused apoptosis requiring the Noxa-Bak axis. In the present study, ab initio a...

Familial amyloid polyneuropathy (FAP) is an autosomal dominant disease associated with the mutations in the transthyretin gene. To date, the endoscopic findings of the small-bowel lesions of FAP have never been described. We report a rare case of FAP with gastrointestinal involvement. A 71-year-old woman complaining of refractory diarrhea for 1 year was referred to our institution. She had sens...

In the seismic design of a reinforced concrete building, selecting appropriate response reduction factor (R) is vital for building’s response. Indian Standard (IS) 1893-2016 provides R values 3 and 5 ordinary moment resisting frames special frames, respectively. As factors are used to incorporate non-linearity, selection should be based on performance in terms resilience. Since IS does not prov...

LETTER FROM ThE CHAIRMAN A POST-~’DRTEM ON CASSM G. Jack Lipovski REVIEW OF ThE ACt4-SIG~OD INTERNATIONAL CONFERENCE ON MANAGEMENT OF DATA Carlo Zaniolo TC/DBE IVEMBERSHIP APPLICATION FORM USER INTERFACE MULTILEVEL SECIRITY ISSUES INA TRANSACT! ON-OR I ENTED DATA BASE MANAGEMENT SYSTEM Stanley R. Ames, Jr. BOOK REVIEW -DATA BASE DESIGN BY GIO WIEDERHOLD John Grant Page 15 CALL FOR ABSTRACTS IN ...

OBJECTIVE To compare the effects of deep breathing exercises (DBE) and the flow-oriented incentive spirometry (IS) in patients undergone coronary artery bypass grafting (CABG) through the following variables: forced vital capacity - FVC, forced expiratory volume in 1 second - FEV(1), maximal respiratory pressures and oxygen saturation. METHODS Thirty six patients in CABG postoperative period ...