Here, we describe the in-plane patterning of thin films of poly(acrylic acid) (PAA) within microfluidic channels by crosslinking with metal cations. The patterned polymer and embedded metal ions (Pb, Ba, Zn, Pd, Cu, La, or Ho) are a platform for the rapid “on-chip” growth of patterned metallic and semiconductor nanoparticles; these particles, in turn, serve as catalysts for electroless depositi...

Cells Sergey V. Morozov, Arkady A. Karyakin, Paulette M. Vignais, Serge Cosnier Faculty of Chemistry, M.V.Lomonosov Moscow State University, 119992, Moscow, Russia CEA/Grenoble, BBSI (UMR CEA/CNRS/UJF no. 5092), DRDC, 38054 Grenoble Cedex 9, France 3 LEOPR (UMR CNRS no. 5630), UJF, BP 53, 38041 Grenoble Cedex 9, France Molecular hydrogen is considered nowadays as the most promising chemical fue...

Microbial transformation of bile acids at the 3a-, 7aand 12a-hydroxyl positions, under anaerobic conditions, was first reported in Alcaligenes fueculis (Hughes & Schmidt, 1942). Other gut bacteria have also been shown to contain hydroxy steroid dehydrogenases (Aries & Hill, 1970). The most common of the three reactions, 7a-hydroxy steroid dehydrogenation, has been reported in many strains of Es...

Introduction Lateral fluid percussion induced traumatic brain injury (TBI) is a clinically relevant rat model of closed head TBI in humans [1]. After primary injury, a complex combination of molecular and cellular alterations occurs in the central nervous system [2] leading to functional disabilities such as somatomotor impairment or epilepsy [3]. This study demonstrates the capability of diffu...

The H-cluster is a complex bridged metal assembly at the active site of [FeFe]-hydrogenases that consists of a [4Fe-4S] subcluster bridged to a 2Fe-containing subcluster with unique nonprotein ligands, including carbon monoxide, cyanide, and a dithiolate ligand of unknown composition. Specific biosynthetic gene products (HydE, HydF, andHydG) responsible for the biosynthesis of the H-cluster and...

Single crys ta l semiconductors (n-Si, p-Si , n -GaAs , p -GaAs , n -GaP, n-In.P, and n -CdS) were coated wi th n t y p e TiO~ by a chemical vapor deposi t ion technique, and the e lec t ron and hole t r ans fe r proper t ies across the he te ro junct ion so produced were invest igated. The qua l i ty of the deposi ted TiO~ film depended upon severa l factors inc luding t empe ra tu r e and sub...

BACTERIAL INFECTIONS HAVE been one of the major scourges of humankind throughout history. Sepsis is recognized as a global health problem with an increasing incidence (5). The rate of hospitalization for sepsis more than doubled between 2000 and 2008 in the US (16). No monotherapy has been successful in improving mortality, including the recent failure of recombinant activated protein C to show...

I remember as a neophyte academician in the early 80’s the excitement and at times heated discussion generated by nitric oxide (NO). How could this toxic and relatively unheard-of gas possibly be a regulatory molecule? Even its discovery was the result of a laboratory mistake (Furchgott, 1995). As with any revolutionary idea, there were both zealous aficionados, naysayers and folks in between t...

•Type B cells are ultrasensitive H2S detectors that integrate distinct danger inputs•Cnga2 and Trpc2 operate in separate subcellular compartments of the same cell•Cnga2 but not is required for detection by type cells•H2S drives stress hormone release, self-grooming, place avoidance The olfactory system serves a critical function as to trigger defense responses essential survival. cellular molec...