BACKGROUND We assessed the suitability of event-related potential frontal and temporoparietal P300 changes as intermediate phenotypes in genetic studies of schizophrenia. We applied a principal component analysis approach based on the notion that P300 abnormalities in siblings of schizophrenic patients may involve a widespread network of relatively weak cortical generators and because an earlie...

OBJECTIVE To evaluate intra-tester reliability of P300 more precisely, this study was designed. Event-related potential (ERP) is the result of endogenous brain response following cognitive stimulus. The P300 component of the human ERP is a positive wave with a latency of 300 ms or greater. Our purpose of this study was to estimate reliability of P300 latency and amplitude with 30 normal persons...

The E2 proteins of papillomaviruses (PV) bind to the coactivator CBP/p300 as do many other transcription factors, but the precise role of CBP/p300 in E2-specific functions is not yet understood. We show that the E2 protein of human PV type 8 (HPV8) directly binds to p300. Activation of HPV8 gene expression by low amounts of HPV8 E2 was stimulated up to sevenfold by coexpression of p300. The int...

The primary transforming functions of simian virus 40 large T antigen (SV40 LT) are conferred primarily through the binding and inactivation of p53 and the retinoblastoma family members. Normal p53 function requires an association with the CREB binding protein (CBP)/p300 coactivators, and a ternary complex containing SV40 LT, p53, and CBP/p300 has been identified previously. In this report, we ...

BACKGROUND Schizophrenia is associated with central (sagittal) midline reductions of the P300 cognitive event-related potential and topographic asymmetry of P300, with reduced left temporal voltage. This P300 asymmetry is, in turn, linked to tissue volume asymmetry in the posterior superior temporal gyrus. However, it is unknown whether P300 asymmetry is specific to schizophrenia and whether ce...

INTRODUCTION In patients with multiple sclerosis among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes. GOAL The aim of this study was to demonstrate that patients with multiple sclerosis have reduced amplitude and prolonged latency, longer than 300 ± 10 ms. METHODS The study included group of patients with multiple sclerosis and control group. After rev...

The P300-based brain-computer interface (P300 BCI) is currently a very popular topic in assistive technology development. However, only a few simple P300 BCI based-games have been designed so far. Here, we analyze the shortcomings of this BCI in gaming applications and show that solutions for overcoming them already exist, although these techniques are dispersed over several different games. Ad...

Because of the great sensitivity of P300 determined in prior research, the aim of this study was to investigate the mediate impact of some biological determinants of P300 on its relationship with extraversion. The sample consisted of 54 female psychology students, right-handers, in the age range of 19-23 years. The P300 was measured by visual oddball paradigm in two trials using EMG/EP device M...

The auditory P300 evoked potential was recorded in 36 subjects: left(LH) and right-handed (RH) schizophrenic males and LH and RH normal controls. LH and RH normals showed no asymmetry in P300 scalp topography. LH and RH schizophrenics, however, showed lateralized asymmetries in temporal scalp regions: left < right P300 voltage asymmetry in RH schizophrenics and left > right P300 voltage asymmet...