This research purposes to develop practical tools to evaluate the effects of ETC (Electric Toll Collection) system on road networks. In this paper, the analytical methodology to evaluate the capacity of toll plaza with ETC is proposed at first. Subsequently, two exiting simulation models, AVENUE and SOUND, are extended to estimate the total effects of ETC on road networks. After these two model...

Toll-like receptors comprise a family of cell surface receptors that play a crucial role in the innate immune recognition of both Drosophila and mammals. Previous studies have shown that Drosophila Toll-1 mediates the induction of antifungal peptides during fungal infection of adult flies. Through genetic studies, Tube, Pelle, Cactus, and Dif have been identified as downstream components of the...

The Capital Beltway HOT Lanes will be a 14 mile subset of the Washington, D.C. region‟s Capital Beltway (Interstate 495) upon completion in December 2012. Buses, carpools (HOV3+), motorcycles and emergency vehicles will be able to access the Capital Beltway HOT lanes for free while drivers with fewer than three occupants must pay a toll to use the HOT lanes. Upon opening, they will be among the...

Determination of dorsal/ventral polarity in Drosophila requires 12 genetically defined, maternally encoded proteins. These include Toll, a transmembrane receptor, Pelle, a ser/thr protein kinase and Tube, all of which function intracytoplasmically to initiate the cascade that ultimately activates Dorsal, an NF-kappaB family transcription factor. Here we describe biochemical interactions between...

The Toll receptor was first found to function in the dorsoventral patterning pathway of Drosophila embryos. It is activated by a specific protein ligand, Spätzle, generated at ventral positions in the early embryo. Drosophila Toll (dToll) also functions in innate immune responses to Gram-positive bacteria and fungi, and Spätzle is required for this response. We have shown that Spätzle is necess...

In Drosophila, the Toll pathway establishes the embryonic dorsoventral axis and triggers innate immune responses to infection. The transmembrane receptor Toll acts through three death domain-containing proteins, the kinase Pelle and the adapters Tube and MyD88, in signaling to downstream NF-kappaB-like transcription factors. Here, we delineate the critical events in the earliest stages of Toll ...

We study the toll pricing problem when the non-toll costs on the network are not fixed and can vary over time. We assume that users who take their decisions, after the tolls are fixed, have full information of all costs before making their decision. Toll-setter, on the other hand, do not have any information of the future costs on the network. The only information toll-setter have is historical...