Mesothelin is a cell surface associated antigen expressed on mesothelial cells and in some malignant neoplasms. Mesothelin-targeted therapies are in phase I/II clinical trials. The clinicopathologic and prognostic significance of mesothelin expression in triple negative breast carcinomas (TNBC) has not been fully assessed. We evaluated the expression of mesothelin and of basal markers in tissue...

Mutations in striated muscle alpha-tropomyosin (alpha-TM), an essential thin filament protein, cause both dilated cardiomyopathy (DCM) and familial hypertrophic cardiomyopathy. Two distinct point mutations within alpha-tropomyosin are associated with the development of DCM in humans: Glu40Lys and Glu54Lys. To investigate the functional consequences of alpha-TM mutations associated with DCM, we ...

BACKGROUND Ghrelin is a 28-amino acid peptide that predominantly produced by the stomach. Strong evidence indicates the effects of ghrelin in the regulation of metabolic functions and its potential role in the aetiology of obesity. AIM The aim of this study was to investigate the relationship of ghrelin levels with obesity, insulin resistance and glucose in normal and obese subjects. METHOD...

the 60 apparently common carp, cyprinus carpio (mean weight 700g.) divided to two groups (1:control and 2: test) and transferred to 1000 liter indoor fiberglass tanks supplied with static well water, continuous aeration and defined water quality. test group was exposed to 30ppb (low concentration) cadmium as cdcl 2 (merck) control group was without cadmium addition . blood samples were caught r...

for induction of ruminal acidosis, 10 clinically healthy three years old non pregnant female sheep were selected. prior to the infusion of sucrose (0 hour), rumen and blood samples were obtained in order to determine baseline rumen and blood ph, respectively. electrocardiogram (ecg) was also recorded. acute ruminal acidosis was induced experimentally with sucrose at a dose of 18g kg-1 body weig...

seventy seven adult large mixed breed dogs of either sex were included in this study. the animals were randomly divided into four groups and received the following drug combinations intramuscularly: group 1 xylazine (0.5 mg/kg) and acepromazine (0.05 mg/kg), group 2 xylazine (0.8 mg/kg) and acepromazine (0.03 mg/kg), group 3 xylazine (0.3 mg/kg) and acepromazine (0.08 mg/kg) and group 4 xylazin...

introduction: we previously shown that microinjection of glutamate into the hdb of rat elicited cardiovascular depressive responses. microinjection of ap5 (an nmda receptor antagonist, 2.5 mm, 50 nl) and cnqx (an ampa receptor antagonist, 1 mm, 50 nl) caused no significant changes in the blood pressure and heart rate. microinjection of bicuculline (bmi: a gabaa receptor antagonist, 1 mm, 50 nl)...