The U, 72.011(1type IV collagenase (matrix metalloproteinase 2 (MMP2)] is known to play a central role in the process of invasion and metas tasis, but its regulation is not clearly understood. We investigated the role of the type I insulin-like growth factor (IGF-I) in the regulation of tumor cell invasion and the synthesis of MMP-2. Highly invasive murine Lewis lung carcinoma subline H-59 cell...

background: laron syndrome, is a disease that treated by igf-1. this protein is a single chain and has three disulfide bonds. people with laron syndrome have low rates of cancer and diabetes, although they appear to be at increased risk of casual death due to their stature. igf-1 is synthesized by many tissues and is secreted from liver as an endocrine hormone which is transmitted to other tiss...

Type 2 Diabetes Mellitus (Type DM) is a metabolic disorder group with mechanisms that include hyperglycemia, insulin resistance and hyperinsulinemia. DM has close association IGF-1, where the active form of IGF-1 becomes elevated by reason fact hyperinsulinemia inhibits production IGF-binding proteins (IGFBP) 1/IGFBP 2. The ability to promote cell proliferation inhibit apoptosis, hence one risk...

introduction: adenotonsillar hypertrophy (ath) may present with growth retardation. insulin-like growth factor 1 (igf-1) mediates the anabolic effects of growth hormone (gh) on tissues. most of the circulating igf-1 molecules are bound to insulin-like growth factor-binding protein 3 (igfbp-3). igf-1 and igfbp-3 serum levels reflect the levels of daily mean serum gh and are used as indices for e...

Plasma Leptin (LEP) and Insulin-like Growth Factor-1 (IGF-1), related to growth puberty onset, were assayed in growing buffalo heifers from 8 up 21 months of age, reared feedlot (FR, n = 13; initial body weight 132 ± 11 Kg) or grazing at pasture (PG, 137 12 Kg). The mean age was not different between the two groups (599.5 610.5 days, FR PG, respectively). At puberty, showed higher BCS, average ...