A novel hybrid consisting of quinazoline and adenine moieties has been synthesized as a precursor of a potential biologically active target compound. The structure of 9-(4-methoxyquinazolin-2-yl)-9H-purin-6-amine (2) was characterized and confirmed using the following spectroscopic methods: LC-UV-MS, 1H-NMR, 13C-NMR and HSQC-NMR.

In this paper, we report the crystal structure of 2-[2-(diphenylphosphoryl)phenyl]-1H-perimidine (L1) obtained from ring closure reaction 1,8-diaminonaphthalene and 2-(diphenylphosphino)benzaldehyde, followed by dehydrogenation with sodium metabisulfite (Na2S2O5). L1 was characterised using 1H, 13C & 31P NMR, FT-IR X-ray single analyses.

Reagents were obtained from commercial suppliers and used as received. Lipase preparation PSIm was purchased from Amano Enzyme Inc. The other lipases were purchased from Sigma-Aldrich. 1H-NMR and 13C-NMR data were recorded on a Bruker Avance 400 (100) MHz and/or a Bruker Avance 500 (125) MHz, respectively. Chemical shifts are reported as δ values (ppm) with CDCl3 (1H-NMR δ 7.26, 13C-NMR δ 77.16...

Although less sensitive than mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy provides a powerful complementary technique for the identification and quantitative analysis of plant metabolites either in vivo or in tissue extracts. In one approach, metabolite fingerprinting, multivariate analysis of unassigned 1H NMR spectra is used to compare the overall metabolic compositio...

This study describes the NMR-based method to determine the limit of quantitation (LOQ) and limit of detection (LOD) of cholesterol, a process-related impurity in the replication-deficient Herpes Simplex Virus (HSV) type 2 candidate vaccine HSV529. Three signature peaks from the 1D 1H NMR of a cholesterol reference spectrum were selected for the identification of cholesterol. The LOQ for a chole...

The preparation of β-meso directly linked porphyrin-corrole hybrids was realized for the first time via an InCl3-catalyzed condensation reaction of 2-formyl-5,10,15,20-tetraphenylporphyrins with meso-substituted dipyrromethanes. Hybrid compounds have been characterized by 1H NMR, 13C NMR, 2D NMR, UV-vis absorption and fluorescence spectroscopy.