OBJECTIVE Lupus anticoagulant and anticardiolipin antibodies (aCL) have been associated with thrombosis, recurrent abortion, and thrombocytopenia in patients with systemic lupus erythematosus (SLE), but their relationship with cardiac disease is less clear. The purpose of this study was to evaluate the association between antiphospholipid antibodies (aPL) and echocardiographic abnormalities in ...

Background: Primary antibody deficiency, the most common primary immunodeficiency disorder, represents a heterogeneous spectrum of conditions caused by a defect in any critical stage of B cell development and is characterized by impaired production of normal amounts of antigen-specific antibodies. Objective: This retrospective study aimed at description and analysis of demographic, clinical, im...

BACKGROUND Anterior cruciate ligament (ACL) injury increases the risk of meniscus and articular cartilage damage, but the causes are not well understood. Previous in vitro studies were static, required extensive knee dissection, and likely altered meniscal and cartilage contact due to the insertion of pressure sensing devices. HYPOTHESIS ACL deficiency will lead to increased translation of th...

background: b-thalassemia major is a serious medical problem. growth retardation is commonly seen in poly-transfused b- thalassemia patients. the exact mechanism of short stature in children with thalassemia major is not well understood, however, it is believed to be multi-factorial. objective: to study the growth state and its relationship to growth hormone (gh) deficiency in b-thalassemia pat...

Anterior cruciate ligament (ACL) reconstruction restores knee stability but does not reduce the incidence of posttraumatic osteoarthritis induced by inflammatory cytokines. The aim of this research was to longitudinally measure IL-1β, IL-6, IL-8, IL-10, and TNF-α levels in patients subjected to ACL reconstruction using bone-patellar tendon-bone graft. Synovial fluid was collected within 24-72 h...

Abstract Background Anterior cruciate ligament (ACL) injury increases risk for post traumatic knee osteoarthritis. ACL causes lack of stability and frequently requires ACL-reconstruction (ACLR) in order to restore functional anatomical joint stability. Magnetic resonance imaging with T2 mapping sequence is used quantify the amount water content articular cartilage hence; it considered a better ...

BACKGROUND The Lachman and pivot-shift tests have been widely used for detecting anterior cruciate ligament (ACL) deficiency. However, it still remains unclear whether these manual tests can be quantified accurately while patients are awake. PURPOSE To assess the differences in knee kinematics of awake and anesthetized patients. STUDY DESIGN Case series; Level of evidence, 4. METHODS A to...

BACKGROUND The management of degenerative arthritis of the knee in the younger, active patient presents a challenge to the orthopaedic surgeon. Surgical treatment options include high tibial osteotomy (HTO), unicompartmental knee arthroplasty, and total knee arthroplasty. PURPOSE To examine the long-term survival of closing wedge HTO in a large series of patients up to 19 years after surgery....