It is intriguing that during human cultural evolution man has detected plant natural products that appear to target key protein receptors of important physiological systems rather selectively. Plants containing such secondary metabolites usually belong to unique chemotaxa, induce potent pharmacological effects and have typically been used for recreational and medicinal purposes or as poisons. C...

Background Previous guidelines (2006) recommended that tumour necrosis factor inhibitors (TNFi) be discontinued during pregnancy. Despite new (2016 & 2020) now recommending against this, the choice to stop TNFi pre-conception is patient- and provider-dependent. Observational studies have evaluated use of disease-modifying anti-rheumatic drugs (DMARDs) pregnancy, but few specifically assesse...

OBJECTIVE Recent epidemiologic studies worldwide have documented a rise in prevalence rates for autism spectrum disorders (ASD). Broadening of diagnostic criteria for ASD may be a major contributor to the rise in prevalence, particularly if superimposed on an underlying continuous distribution of autistic traits. This study sought to determine the nature of the population distribution of autist...

conclusions findings of the study demonstrated that the t. gondii infection is common in wild boars in southwest iran and could represent a significant health risk for animals, hunters, and local residents who may consume wild boar meat. results anti-t. gondii antibodies were detected in sera of 4 out of the 25 (16%) wild boars. there was no gender or age-related differences in seroprevalence o...