Background and purpose: Sedation is regarded as a common side effect of most antihistamines, and limits the clinical utility of classical antihistaminic agents, while newer antihistamines are nonsedating. Çonsidering the importance of this phenomenon in the present study, the role of different histamine receptor mechanisms in mediating the sedation were investigated in rat rota rod test. M...

Background and purpose: Histamine is a neurotransmitter present in the brain of mammals which produces its physiological effects on target cells by stimulation of three types of receptors H1, H2 and H3. Various reports nowadays indicate the role of histamine in reduction of pain transmission. This study was designed to determine the role of histamine receptors in reduction of pain. Mate...