Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, w...

epilepsy is a disorder categorized by recurrent seizures and leads to changes in neuronal death and neurogenesis. recently the search for new targets in the therapy of epilepsy has focused on brain inflammation because brain inflammation and the associate blood brain barrier damage appears to be basic part of epilepsy pathophysiology-erythropoietin (epo) regulates biological processes counting ...

Altered gait kinematics in individuals with functional ankle instability (FAI) are thought to contribute to instability; however, research fi ndings are inconsistent. Findings may be clarifi ed with the use of a multisegment foot model and a coper group. Participants included 69 individuals: 23 with FAI, 23 controls, and 23 copers (individuals with a history of ankle sprain but no instability)....

The aim of this work was to fabricate a novel nano-fiber modified electrode, involving Lake Red C (LRC) pigments doped into electrospun polyacrylonitrile (PAN) fibrous films. Cyclic voltammetry (CV), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) techniques were used for electrochemical and morphological characterization...

Sulfurized polyacrylonitrile (SPAN) is one of the most important sulfurized carbon materials that can potentially be coupled with the carbonaceous anode to fabricate a safe and low cost “all carbon” lithium-ion battery. However, its chemical structure and electrochemical properties have been poorly understood. In this discussion, we analyze the previously published data in combination with our ...